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Post-translational modifications of PRC2: signals directing its activity
Yang,Yiqi1,2,3; Li,Gang1,2,3
2020-12-01
Source PublicationEpigenetics and Chromatin
Volume13Issue:1
Abstract

Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain.

KeywordCgis Cis Chromatin Features Facultative Subunits Methylation Phosphorylation Prc2 Ptms Ubiquitination
DOI10.1186/s13072-020-00369-1
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000583172100001
Scopus ID2-s2.0-85094638852
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLi,Gang
Affiliation1.Faculty of Health Sciences,University of Macau,Macao
2.Cancer Centre,Faculty of Health Sciences,University of Macau,Macao
3.Centre of Reproduction,Development and Aging,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao
First Author AffilicationFaculty of Health Sciences;  Cancer Centre
Corresponding Author AffilicationFaculty of Health Sciences;  Cancer Centre
Recommended Citation
GB/T 7714
Yang,Yiqi,Li,Gang. Post-translational modifications of PRC2: signals directing its activity[J]. Epigenetics and Chromatin,2020,13(1).
APA Yang,Yiqi,&Li,Gang.(2020).Post-translational modifications of PRC2: signals directing its activity.Epigenetics and Chromatin,13(1).
MLA Yang,Yiqi,et al."Post-translational modifications of PRC2: signals directing its activity".Epigenetics and Chromatin 13.1(2020).
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