The roles of microRNAs in regulating the expression of PD-1/PD-l1 immune checkpoint
Wang,Qingshui1,2; Lin,Wei3; Tang,Xiaoqiong1; Li,Suhuan1; Guo,Libin2; Lin,Yao1; Kwok,Hang Fai2
Source PublicationInternational Journal of Molecular Sciences
AbstractEngagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint.
KeywordImmune checkpoint MicroRNAs Programmed death 1(PD-1) Programmed death-ligand 1 (PD-L1)
URLView the original
Scopus ID2-s2.0-85035756051
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Cited Times [WOS]:58   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorKwok,Hang Fai
Affiliation1.Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation,College of Life Sciences,Fujian Normal University,Fuzhou,350117,China
2.Faculty of Health Sciences,University of Macau,Avenida de Universidade,Taipa,Macao
3.Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,350112,China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wang,Qingshui,Lin,Wei,Tang,Xiaoqiong,et al. The roles of microRNAs in regulating the expression of PD-1/PD-l1 immune checkpoint[J]. International Journal of Molecular Sciences,2017,18(12).
APA Wang,Qingshui,Lin,Wei,Tang,Xiaoqiong,Li,Suhuan,Guo,Libin,Lin,Yao,&Kwok,Hang Fai.(2017).The roles of microRNAs in regulating the expression of PD-1/PD-l1 immune checkpoint.International Journal of Molecular Sciences,18(12).
MLA Wang,Qingshui,et al."The roles of microRNAs in regulating the expression of PD-1/PD-l1 immune checkpoint".International Journal of Molecular Sciences 18.12(2017).
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