BRCA1 and estrogen/estrogen receptor in breast cancer: Where they interact?
Wang,Li; Di,Li Jun
Source PublicationInternational Journal of Biological Sciences
AbstractBRCA1 mainly acts as a tumor suppressor and BRCA1 mutation correlates with increased cancer risk. Although it is well recognized that BRCA1 related tumorigenesis is mainly caused by the increased DNA damage and decreased genome stability, it is not clear that why BRCA1 related patients have higher risk for cancer development mainly in estrogen responsive tissues such as breast and ovary. Recent studies suggested that BRCA1 and E-ER (estrogen and estrogen receptor) signaling synergistically regulate the mammary epithelial cell proliferation and differentiation. In this current presentation, we reviewed the correlation between mammary gland epithelial cell transformation and the status of BRCA1 and ER. Then the mechanisms of BRCA1 and E-ER interaction at both gene transcription level and protein-protein interaction level are discussed. Furthermore, the tumorigenic mechanisms are discussed by focusing on the synergistic effect of BRCA1 and E-ER on cell metabolism, ROS management, and antioxidant activity in mammary gland epithelial cells. Also, the possibility of cell de-differentiation promoted by coordinated effect between BRCA1 mutation and E-ER signal is explored. Together, the currently available evidences suggest that BRCA1 mutation and E-ER signal together, contribute to breast tumorigenesis by providing the metabolic support for cancer cell growth and even may directly be involved in promoting the de-differentiation of cancer-prone epithelial cells. © Ivyspring International Publisher.
KeywordBRCA1 Breast cancer Cell metabolism Estrogen Estrogen receptor Mammary gland development Oxidative stress ROS
URLView the original
Scopus ID2-s2.0-84900794136
Fulltext Access
Citation statistics
Cited Times [WOS]:36   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationUniversity of Macau,Macao
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang,Li,Di,Li Jun. BRCA1 and estrogen/estrogen receptor in breast cancer: Where they interact?[J]. International Journal of Biological Sciences,2014,10(5):563-573.
APA Wang,Li,&Di,Li Jun.(2014).BRCA1 and estrogen/estrogen receptor in breast cancer: Where they interact?.International Journal of Biological Sciences,10(5),563-573.
MLA Wang,Li,et al."BRCA1 and estrogen/estrogen receptor in breast cancer: Where they interact?".International Journal of Biological Sciences 10.5(2014):563-573.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang,Li]'s Articles
[Di,Li Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang,Li]'s Articles
[Di,Li Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang,Li]'s Articles
[Di,Li Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.