UM
Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B
Yan,Fengxia1,2; Liao,Rifang1,2; Lin,Shaofen1; Deng,Xianguo1; Little,Peter J.3; Zheng,Wenhua1,2
2018-02-01
Source PublicationMolecular Medicine Reports
ISSN1791-2997
Volume17Issue:2Pages:3109-3114
AbstractForkhead box protein O3 (FoxO3a) is a forkhead box family transcription factor which serves an important role in a number of biological functions, including tumor growth. A previous study indicated that FoxO3a serves a role in insulin like growth factor-induced growth, migration and invasion of uveal melanoma (UM) cells; however, whether FoxO3a is associated with the development and formation of UM remains unknown. In the present study, the role of FoxO3a in UM development and formation was investigated by modulating the expression of FoxO3a in a human UM cell line. The results of the present study demonstrated that FoxO3a overexpression in UM cells inhibited cell proliferation and promoted cellular apoptosis, leading to an accumulation of cells at the G1 cell cycle phase. Western blot analysis demonstrated that FoxO3a overexpression increased the transcription and protein expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B, and inhibited cyclin D1 transcription and expression. The opposite effects were observed when FoxO3a was knocked down in UM cells. The results of the present study indicated that FoxO3a may exhibit a negative role in UM development and formation, which is consistent with its role as a tumor suppressor.
KeywordCell cycle phase Forkhead box protein O3 Uveal melanoma Uveal melanoma cells
DOI10.3892/mmr.2017.8215
URLView the original
Language英语
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZheng,Wenhua
Affiliation1.School of Pharmaceutical Sciences,State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou, Guangdong,510060,China
2.Faculty of Health Sciences,University of Macau,Taipa, Macau SAR,Avenida de Universidade,519020,Macao
3.School of Pharmacy,Pharmacy Australia Centre of Excellence,University of Queensland,Woolloongabba,4102,Australia
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yan,Fengxia,Liao,Rifang,Lin,Shaofen,et al. Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B[J]. Molecular Medicine Reports,2018,17(2):3109-3114.
APA Yan,Fengxia,Liao,Rifang,Lin,Shaofen,Deng,Xianguo,Little,Peter J.,&Zheng,Wenhua.(2018).Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B.Molecular Medicine Reports,17(2),3109-3114.
MLA Yan,Fengxia,et al."Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B".Molecular Medicine Reports 17.2(2018):3109-3114.
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