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The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development
Farhan,Mohd1; Silva,Marta1; Li,Shuai1; Yan,Fengxia2; Fang,Jiankang1; Peng,Tangming1; Hu,Jim3; Tsao,Ming Sound3; Little,Peter4; Zheng,Wenhua1
2020-11-01
Source PublicationMedicinal Research Reviews
ISSN0198-6325
Volume40Issue:6Pages:2089-2113
AbstractAutophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of cancer growth and metastasis. Recent evidence suggests that FOXO proteins are also involved in autophagy regulation. The relationship among FOXOs, autophagy, and cancer has been drawing attention of many who work in the field. This study summarizes the role of FOXO proteins and autophagy in cancer growth and metastasis and analyzes their potential roles in cancer disease management.
Keywordautophagy cancer FOXO proteins metastasis
DOI10.1002/med.21695
URLView the original
Language英语
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZheng,Wenhua
Affiliation1.Faculty of Health Sciences,Centre of Reproduction,Development and Aging,Institute of Translational Medicine,University of Macau,Taipa,Macao
2.Department of Medicine,Jinan University,Guangzhou,China
3.Department of Laboratory Medicine and Pathobiology,University of Toronto,Toronto,Canada
4.School of Pharmacy,Pharmacy Australia Centre of Excellence,The University of Queensland,Woolloongabba,Australia
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Farhan,Mohd,Silva,Marta,Li,Shuai,et al. The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development[J]. Medicinal Research Reviews,2020,40(6):2089-2113.
APA Farhan,Mohd,Silva,Marta,Li,Shuai,Yan,Fengxia,Fang,Jiankang,Peng,Tangming,Hu,Jim,Tsao,Ming Sound,Little,Peter,&Zheng,Wenhua.(2020).The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development.Medicinal Research Reviews,40(6),2089-2113.
MLA Farhan,Mohd,et al."The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development".Medicinal Research Reviews 40.6(2020):2089-2113.
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