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Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China
Li,Qian1; Xiang,Yu Tao2; Su,Yun Ai1; Shu,Liang1; Yu,Xin1; Chiu,Helen F.K.3; Correll,Christoph U.4; Ungvari,Gabor S.5; Lai,Kelly Y.C.3; Ma,Cui6; Wang,Gao Hua7; Bai,Pei Shen8; Li,Tao9; Sun,Li Zhong10; Shi,Jian Guo11; Chen,Xian Sheng12; Mei,Qi Yi13; Li,Ke Qing14; Si,Tian Mei1
2015-02-22
Source PublicationAustralian and New Zealand Journal of Psychiatry
ISSN0004-8674
Volume49Issue:2Pages:129-136
AbstractObjective: This study examined the use, demographic and clinical correlates of antipsychotic polypharmacy (APP) and its associations with treatment satisfaction and quality of life (QOL) in schizophrenia patients in China. Method: A total of 4239 patients in 45 nationwide Chinese psychiatric hospitals/centers were interviewed in 2012 in the third cross-sectional study, with the first two having been conducted in 2002 and 2006. Patients' socio-demographic and clinical characteristics, including psychopathology, side effects, satisfaction with treatment and QOL, were recorded using a standardized protocol and data collection procedure. Results: The proportion of APP prescriptions in 2012 was 34.2%, which was significantly higher than the frequency of APP in 2002 (26.1%) and 2006 (26.4%) (p<0.001). Of patients on APP, 91.1% received two antipsychotics, 8.6% received three and 0.3% received four or more antipsychotics. Multiple logistic regression analyses revealed that compared to those on antipsychotic monotherapy, patients on APP and their families had lower satisfaction with treatment, had higher QOL in the mental domain, younger age of onset, more side effects, higher doses of antipsychotics and were more likely to receive first-generation antipsychotics and less likely to receive benzodiazepines (total R2=0.31, p<0.001). Conclusions: APP was found in about one in three schizophrenia patients. The prevalence of APP seems to have been increasing since 2002. Considering the increased frequency of drug-induced side effects and the patients' and their relatives' dissatisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of APP and its alternatives is warranted.
KeywordAntipsychotic polypharmacy prescription patterns schizophrenia
DOI10.1177/0004867414536931
URLView the original
Language英语
Scopus ID2-s2.0-84921350985
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Cited Times [WOS]:27   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Key Laboratory of Mental Health, Ministry of Health, Peking University Institute of Mental Health,Beijing,China
2.Faculty of Health Sciences, University of Macau,Macao
3.Department of Psychiatry, Chinese University of Hong Kong,Hong Kong,Hong Kong
4.Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System,Glen Oaks,United States
5.University of Notre Dame Australia/Marian Centre,Perth,Australia
6.Psychiatric Hospital,Guangzhou,China
7.Department of Psychiatry, Renmin Hospital, Wuhan University,Wuhan,China
8.First Hospital of Shanxi Medical University,Shanxi Province,China
9.West China Hospital, Sichuan University,China
10.Neuropsychiatric Hospital,Jilin,China
11.Mental Health Center,Xi-an,China
12.Jiangxi Psychiatric Hospital,Jiangxi,China
13.Suzhou Guangji Hospital,Suzhou,China
14.Hebei Mental Health Center,Hebei,China
Recommended Citation
GB/T 7714
Li,Qian,Xiang,Yu Tao,Su,Yun Ai,et al. Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China[J]. Australian and New Zealand Journal of Psychiatry,2015,49(2):129-136.
APA Li,Qian,Xiang,Yu Tao,Su,Yun Ai,Shu,Liang,Yu,Xin,Chiu,Helen F.K.,Correll,Christoph U.,Ungvari,Gabor S.,Lai,Kelly Y.C.,Ma,Cui,Wang,Gao Hua,Bai,Pei Shen,Li,Tao,Sun,Li Zhong,Shi,Jian Guo,Chen,Xian Sheng,Mei,Qi Yi,Li,Ke Qing,&Si,Tian Mei.(2015).Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China.Australian and New Zealand Journal of Psychiatry,49(2),129-136.
MLA Li,Qian,et al."Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China".Australian and New Zealand Journal of Psychiatry 49.2(2015):129-136.
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