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Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia
Liu,Dengtang1; Ji,Chengfeng1; Zhuo,Kaiming1; Song,Zhenhua1; Wang,Yingchan1; Mei,Li1; Zhu,Dianming1; Xiang,Qiong1; Chen,Tianyi1,2; Yang,Zhilei1,3; Zhu,Guang1,2; Wang,Ya4,8; Cheung,Eric F.C.5; Xiang,Yu Tao6; Fan,Xiaoduo7; Chan,Raymond C.K.4; Xu,Yifeng1; Jiang,Kaida1
2017-03-01
Source PublicationAustralian and New Zealand Journal of Psychiatry
ISSN0004-8674
Volume51Issue:3Pages:270-277
AbstractObjective: Schizophrenia is associated with impairment in prospective memory, the ability to remember to carry out an intended action in the future. It has been established that cue identification (detection of the cue event signaling that an intended action should be performed) and intention retrieval (retrieval of an intention from long-term memory following the recognition of a prospective cue) are two important processes underlying prospective memory. The purpose of this study was to examine prospective memory deficit and underlying cognitive processes in patients with first-episode schizophrenia. Methods: This study examined cue identification and intention retrieval components of event-based prospective memory using a dual-task paradigm in 30 patients with first-episode schizophrenia and 30 healthy controls. All participants were also administered a set of tests assessing working memory and retrospective memory. Results: Both cue identification and intention retrieval were impaired in patients with first-episode schizophrenia compared with healthy controls (ps < 0.05), with a large effect size for cue identification (Cohen's d = 0.98) and a medium effect size for intention retrieval (Cohen's d = 0.62). After controlling for working memory and retrospective memory, the difference in cue identification between patients and healthy controls remained significant. However, the difference in intention retrieval between the two groups was no longer significant. In addition, there was a significant inverse relationship between cue identification and negative symptoms (r = '0.446, p = 0.013) in the patient group. Conclusion: These findings suggest that both cue identification and intention retrieval in event-based prospective memory are impaired in patients with first-episode schizophrenia. Cue identification and intention retrieval could be potentially used as biomarkers for early detection and treatment prognosis of schizophrenia. In addition, addressing cue identification deficit through cognitive enhancement training may potentially improve negative symptoms as well.
Keywordcue identification first-episode intention retrieval Prospective memory schizophrenia
DOI10.1177/0004867416640097
URLView the original
Language英语
Scopus ID2-s2.0-85013288205
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLiu,Dengtang
Affiliation1.First-episode Schizophrenia and Early Psychosis Program,Division of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,600 Wan Ping Nan Road,200030,China
2.Shanghai Hongkou Mental Health Center,Shanghai,China
3.Jiading Mental Health Center,Shanghai,China
4.Neuropsychology and Applied Cognitive Neuroscience Laboratory,Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Science,Beijing,China
5.Castle Peak Hospital,Hong Kong,Hong Kong
6.Unit of Psychiatry,Faculty of Health Sciences,University of Macau,Macao
7.Psychotic Disorders Program,UMass Memorial Medical Center,University of Massachusetts Medical School,Worcester,United States
8.Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China
Recommended Citation
GB/T 7714
Liu,Dengtang,Ji,Chengfeng,Zhuo,Kaiming,et al. Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia[J]. Australian and New Zealand Journal of Psychiatry,2017,51(3):270-277.
APA Liu,Dengtang,Ji,Chengfeng,Zhuo,Kaiming,Song,Zhenhua,Wang,Yingchan,Mei,Li,Zhu,Dianming,Xiang,Qiong,Chen,Tianyi,Yang,Zhilei,Zhu,Guang,Wang,Ya,Cheung,Eric F.C.,Xiang,Yu Tao,Fan,Xiaoduo,Chan,Raymond C.K.,Xu,Yifeng,&Jiang,Kaida.(2017).Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia.Australian and New Zealand Journal of Psychiatry,51(3),270-277.
MLA Liu,Dengtang,et al."Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia".Australian and New Zealand Journal of Psychiatry 51.3(2017):270-277.
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