UM
Adjunctive memantine for major mental disorders: A systematic review and meta-analysis of randomized double-blind controlled trials
Zheng,Wei1; Zhu,Xiao Min2; Zhang,Qing E.3; Cai,Dong Bin4; Yang,Xin Hu1; Zhou,Yan Ling1; Ungvari,Gabor S.5,6; Ng,Chee H.7; He,Shu Hua8; Peng,Xiao Jiang9; Ning,Yu Ping1; Xiang,Yu Tao10
2019-07-01
Source PublicationSchizophrenia Research
ISSN0920-9964
Volume209Pages:12-21
AbstractObjective: As a non-competitive N-methyl-D-aspartate receptor antagonist, memantine has been used to treat major mental disorders including schizophrenia, bipolar disorder, and major depressive disorder (MDD). This meta-analysis systematically investigated the effectiveness and tolerability of adjunctive memantine for patients with schizophrenia, bipolar disorder, and MDD. Methods: Only randomized controlled trials (RCTs) were identified and included in the study. Data of the three disorders were separately synthesized using the RevMan 5.3 software. Results: Fifteen RCTs (n = 988) examining memantine (5–20 mg/day) as an adjunct treatment for schizophrenia (9 trials with 512 patients), bipolar disorder (3 trials with 319 patients), and MDD (3 trials with 157 patients) were analyzed. Memantine outperformed the comparator regarding total psychopathology with a standardized mean difference (SMD) of −0.56 [95% confidence interval (CI): −1.01, −0.11; I = 76%, P = 0.01] and negative symptoms with an SMD of −0.71 (95% CI: −1.09, −0.33; I = 74%, P = 0.0003) in schizophrenia, but no significant effects were found with regard to positive symptoms and general psychopathology in schizophrenia, or depressive and manic symptoms in bipolar disorder or depressive symptoms in MDD. Memantine outperformed the comparator in improving cognitive performance in schizophrenia with an SMD of 1.07 (95% CI: 0.53, 1.61; P < 0.0001, I = 29%). No group differences were found in the rates of adverse drug reactions and discontinuation due to any reason in the three major mental disorders. Conclusions: Memantine as an adjunct treatment appears to have significant efficacy in improving negative symptoms in schizophrenia. The efficacy and safety of adjunctive memantine for bipolar disorder or MDD needs to be further examined. Review registration: PROSPERO: 42018099045.
KeywordBipolar disorder Major depressive disorder Memantine NMDA receptor antagonists Schizophrenia
DOI10.1016/j.schres.2019.05.019
URLView the original
Language英语
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital),Guangzhou,China
2.Suzhou Psychiatric Hospital,The Affiliated Guangji Hospital of Soochow University,Suzhou,China
3.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing,China
4.Clinics of Chinese Medicine,the First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou,China
5.The University of Notre Dame Australia,Fremantle,Australia
6.Division of Psychiatry,School of Medicine,University of Western Australia,Perth,Australia
7.Department of Psychiatry,University of Melbourne,Melbourne,Australia
8.University of California,Davis,United States
9.Guangzhou Civil Aviation College,Guangzhou,China
10.Unit of Psychiatry,Faculty of Health Sciences,University of Macau,Macao SAR,China
Recommended Citation
GB/T 7714
Zheng,Wei,Zhu,Xiao Min,Zhang,Qing E.,et al. Adjunctive memantine for major mental disorders: A systematic review and meta-analysis of randomized double-blind controlled trials[J]. Schizophrenia Research,2019,209:12-21.
APA Zheng,Wei,Zhu,Xiao Min,Zhang,Qing E.,Cai,Dong Bin,Yang,Xin Hu,Zhou,Yan Ling,Ungvari,Gabor S.,Ng,Chee H.,He,Shu Hua,Peng,Xiao Jiang,Ning,Yu Ping,&Xiang,Yu Tao.(2019).Adjunctive memantine for major mental disorders: A systematic review and meta-analysis of randomized double-blind controlled trials.Schizophrenia Research,209,12-21.
MLA Zheng,Wei,et al."Adjunctive memantine for major mental disorders: A systematic review and meta-analysis of randomized double-blind controlled trials".Schizophrenia Research 209(2019):12-21.
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