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Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia
Li,Xian Bin1,2; Wang,Lu Bin3; Xiong,Yan Bing1,2; Bo,Qi Jing1,2; He,Fan1,2; Li,Feng1,2; Hou,Wen Peng1,2; Wen,Yu Jie1,2; Wang,Xue Qi1,2; Yang,Ning Bo1,2; Mao,Zhen1,2; Dong,Qian Hong1,2; Zhang,Fei Fei1,2; Yang,Rui1,2; Wang,Di1,2; Xiang,Yu Tao4,5; Zhu,Yu Yang3; Tang,Yi Lang6; Yang,Zheng1,2,3; Wang,Chuan Yue1,2
2019-12-01
Source PublicationPsychiatry Research
ISSN0165-1781
Volume282
AbstractObjectives: Abnormalities in insular functional connectivity have been implicated in many clinical features of schizophrenia. The aim of this study was to determine to what degree such abnormalities occur in individuals with clinical high risk for psychosis (CHR), and whether which is associated with symptom severity. Methods: Resting-state fMRI data were collected from 47 healthy controls, 24 CHR individuals and 19 patients with first-episode schizophrenia. Using the posterior, dorsal and ventral insular subregions as separate seeds, we examined resting-state functional connectivity differences between different groups and the association between concurrent symptom severity and dysconnectivity. Results: Compared with healthy controls, both CHR individuals and schizophrenia patients showed hypoconnectivity between posterior insula (PI) and somatosensory areas, and between dorsal anterior insula (dAI) and putamen. Schizophrenia patients also showed dAI and ventral anterior insula(vAI) hyperconnectivity with visual areas relative to controls and CHR individuals. Correlation analysis revealed that dAI functional connectivity with superior temporal gyrus was positively correlated with positive symptoms of CHR, and vAI connectivity with dorsolateral prefrontal cortex was negatively correlated with the severity of the symptoms of first-episode schizophrenia. Conclusions: Our findings suggest that insular functional dysconnectivity with the sensory cortex may be a system-level neural substrate preceding the onset of psychosis.
KeywordClinical high-risk Insula Resting-state functional connectivity Schizophrenia
DOI10.1016/j.psychres.2019.112608
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,China
2.Advanced Innovation Center for Human Brain Protection,Capital Medical University,China
3.Institute of Military Cognition and Brain Sciences,Academy of Military Medical Sciences,100850,China
4.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao SAR,China
5.Center for Cognition and Brain Sciences,University of Macau,Macao SAR,China
6.Department of Psychiatry and Behavioral Sciences,Emory University School of Medicine,Atlanta,United States
Recommended Citation
GB/T 7714
Li,Xian Bin,Wang,Lu Bin,Xiong,Yan Bing,et al. Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia[J]. Psychiatry Research,2019,282.
APA Li,Xian Bin,Wang,Lu Bin,Xiong,Yan Bing,Bo,Qi Jing,He,Fan,Li,Feng,Hou,Wen Peng,Wen,Yu Jie,Wang,Xue Qi,Yang,Ning Bo,Mao,Zhen,Dong,Qian Hong,Zhang,Fei Fei,Yang,Rui,Wang,Di,Xiang,Yu Tao,Zhu,Yu Yang,Tang,Yi Lang,Yang,Zheng,&Wang,Chuan Yue.(2019).Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia.Psychiatry Research,282.
MLA Li,Xian Bin,et al."Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia".Psychiatry Research 282(2019).
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