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Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults
Li,Haibin1,2; Zheng,Deqiang1,2; Li,Zhiwei1,2; Wu,Zhiyuan1,2; Feng,Wei1,2; Cao,Xue1; Wang,Jiaxin1; Gao,Qi1,2; Li,Xia3; Wang,Wei4; Hall,Brian J.5,6; Xiang,Yu Tao7,8; Guo,Xiuhua1,2
2019-12-02
Source PublicationJAMA network open
Volume2Issue:12
AbstractImportance: The prevalence of depressive symptoms among older adults has become an increasingly important public health priority. Elevated depressive symptoms are well documented among elderly people with cardiovascular disease (CVD), but studies conducted among Chinese adults are scarce. Objective: To estimate the association between depressive symptoms and incident CVD among middle-aged and older Chinese adults. Design, Setting, and Participants: The China Health and Retirement Longitudinal Study is an ongoing nationally representative prospective cohort study that was initiated in 2011. This cohort study included 12 417 middle-aged and older Chinese adults without heart disease and stroke at baseline. Statistical analysis was conducted from April 25, 2018, to December 13, 2018. Exposure: Depressive symptoms were assessed using the validated 10-item of Center for Epidemiologic Studies Depression Scale. Main Outcomes and Measures: Incident CVD (ie, self-reported physician-diagnosed heart disease and stroke combined) was followed-up from June 1, 2011, to June 31, 2015. The Center for Epidemiologic Studies Depression Scale total score ranges from 0 to 30, with a score of 12 or more indicating elevated depressive symptoms. Results: Of the 12 417 participants (mean [SD] age at baseline, 58.40 [9.51] years), 6113 (49.2%) were men. During the 4 years of follow-up, 1088 incident CVD cases were identified. Elevated depressive symptoms were independently associated with an increased CVD risk (adjusted hazard ratio, 1.39; 95% CI, 1.22-1.58) after adjusting for age, sex, residence, marital status, educational level, smoking status, drinking status, systolic blood pressure, and body mass index; history of diabetes, hypertension, dyslipidemia, and chronic kidney disease; and use of hypertension medications, diabetes medications, and lipid-lowering therapy. Of the 10 individual depressive symptoms measured by the Center for Epidemiologic Studies Depression Scale, only 2 symptoms, restless sleep (adjusted hazard ratio, 1.21; 95% CI, 1.06-1.39) and loneliness (adjusted hazard ratio, 1.21; 95% CI, 1.02-1.44), were significantly associated with incident CVD. Conclusions and Relevance: Elevated depressive symptoms overall and 2 individual symptoms (restless sleep and loneliness) were significantly associated with incident CVD among middle-aged and older Chinese adults.
DOI10.1001/jamanetworkopen.2019.16591
URLView the original
Language英语
Scopus ID2-s2.0-85076123349
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Epidemiology and Health Statistics,Capital Medical University School of Public Health,China
2.Beijing Municipal Key Laboratory of Clinical Epidemiology,Capital Medical University,China
3.Department of Mathematics and Statistics,La Trobe University,Melbourne,Australia
4.Global Health and Genomics,Edith Cowan University School of Medical Health Sciences,Perth,Australia
5.Global and Community Mental Health Research Group,Department of Psychology,University of Macau,China
6.Health,Behavior,Society,Johns Hopkins Bloomberg School of Public Health,Baltimore,United States
7.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,China
8.Center for Cognition and Brain Sciences,University of Macau,China
Recommended Citation
GB/T 7714
Li,Haibin,Zheng,Deqiang,Li,Zhiwei,et al. Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults[J]. JAMA network open,2019,2(12).
APA Li,Haibin,Zheng,Deqiang,Li,Zhiwei,Wu,Zhiyuan,Feng,Wei,Cao,Xue,Wang,Jiaxin,Gao,Qi,Li,Xia,Wang,Wei,Hall,Brian J.,Xiang,Yu Tao,&Guo,Xiuhua.(2019).Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults.JAMA network open,2(12).
MLA Li,Haibin,et al."Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults".JAMA network open 2.12(2019).
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