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Relationship between body mass index and extrapyramidal symptoms in asian patients with schizophrenia: The research on asian psychotropic prescription patterns for antipsychotics (reap-ap)
Park,Seon Cheol1; Tripathi,Adarsh2; Avasthi,Ajit3; Grover,Sandeep3; Tanra,Andi J.4; Kato,Takahiro A.5; Inada,Toshiya6; Chee,Kok Yoon7; Chong,Mian Yoon8; Yang,Shu Yu9; Lin,Sih Ku10; Sim,Kang11; Xiang,Yu Tao12; Javed,Afzal13; Sartorius,Norman14; Shinfuku,Naotaka15; Park,Yong Chon16
2020
Source PublicationPsychiatria Danubina
ISSN0353-5053
Volume32Issue:2Pages:176-186
AbstractBackground: Although an inverse relationship between body mass index (BMI) and Parkinson disease (PD) has been repeatedly reported, to our knowledge, the relationship between BMI and antipsychotic-induced extrapyramidal symptoms (EPS) has rarely been studied in patients with schizophrenia. Our study aimed to evaluate the relationship between BMI and EPS in patients with schizophrenia. Subjects and methods: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP) study, we compared the prevalence of EPS in 1448 schizophrenia patients stratified as underweight, normal range, overweight preobese, overweight obese I, overweight obese II, and overweight obese III according to the World Health Organization (WHO) classification system for body weight status, and with underweight, normal range, overweight at risk, overweight obese I, and overweight obese II according to the Asia-Pacific obesity classification. Results: In the first step of the WHO classification system for body weight status, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with greater rates of bradykinesia and muscle rigidity, and a lower rate of gait disturbance. In the second step of the Asia-Pacific obesity classification, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with a higher rate of muscle rigidity. Conclusion: Findings of the present study consistently revealed that underweight was associated with a greater rate of muscle rigidity in a stepwise pattern among Asian patients with schizophrenia. Although the mechanism underlying the inverse relationship between BMI and muscle rigidity cannot be sufficiently explained, it is speculated that low BMI may contribute to the development of muscle rigidity regardless of antipsychotic "typicality" and dose in patients with schizophrenia.
KeywordAntipsychotics Asian Body mass index (BMI) Extrapyramidal symptoms (eps) Muscle rigidity Schizophrenia
DOI10.24869/PSYD.2020.176
URLView the original
Language英语
Scopus ID2-s2.0-85089514462
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorPark,Yong Chon
Affiliation1.Department of Psychiatry,Inje University Haeundae Paik Hospital,Busan,South Korea
2.Department of Psychiatry,King George's Medical University,Chowk, Lucknow,India
3.Post Graduate Institute of Medical Education and Research (PGIMER),Department of Psychiatry,Chandigarh,India
4.Department of Psychiatry,Faculty of Medicine,Hasanuddin University,Makassar,Indonesia
5.Department of Neuropsychiatry,Graduate School of Medicine,Kyushu University,Fukuoka,Japan
6.Department of Psychiatry and Psychobiology,Graduate School of Medicine,Nagoya University,Nagoya,Japan
7.Tunku Abdul Rahman Institute of Neuroscience,Kuala Lumpur Hospital,Kuala Lumpur,Malaysia
8.Chang Gung University School of Medicine,Chang Gung Memorial Hospital,Chiayi,Taiwan
9.Songde Branch,Tapei City Hospital,Deparment of Pharmacy, Tapei,Taiwan
10.Psychiatric Center,Taipei City Hospital,Taipei,Taiwan
11.Institute of Mental Health and Yong Loo Lin School of Medicine,National University of Singapore,Singapore
12.Faculty of Health Sciences,Institute of Translational Medicine,University of Macau,Macao
13.Pakistan Psychiatric Research Centre,Fountain House,Lahore,Pakistan
14.Association for Improvement of Mental Health Programmes,Geneva,Switzerland
15.Department of Social Welfare,School of Human Sciences,Seinan Gakuin University,Fukuoka,Japan
16.Department of Neuropsychiatry,Hanyang University Guri Hospital,Guri,South Korea
Recommended Citation
GB/T 7714
Park,Seon Cheol,Tripathi,Adarsh,Avasthi,Ajit,et al. Relationship between body mass index and extrapyramidal symptoms in asian patients with schizophrenia: The research on asian psychotropic prescription patterns for antipsychotics (reap-ap)[J]. Psychiatria Danubina,2020,32(2):176-186.
APA Park,Seon Cheol,Tripathi,Adarsh,Avasthi,Ajit,Grover,Sandeep,Tanra,Andi J.,Kato,Takahiro A.,Inada,Toshiya,Chee,Kok Yoon,Chong,Mian Yoon,Yang,Shu Yu,Lin,Sih Ku,Sim,Kang,Xiang,Yu Tao,Javed,Afzal,Sartorius,Norman,Shinfuku,Naotaka,&Park,Yong Chon.(2020).Relationship between body mass index and extrapyramidal symptoms in asian patients with schizophrenia: The research on asian psychotropic prescription patterns for antipsychotics (reap-ap).Psychiatria Danubina,32(2),176-186.
MLA Park,Seon Cheol,et al."Relationship between body mass index and extrapyramidal symptoms in asian patients with schizophrenia: The research on asian psychotropic prescription patterns for antipsychotics (reap-ap)".Psychiatria Danubina 32.2(2020):176-186.
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