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Comparison of cognitive dysfunction between schizophrenia and bipolar disorder patients: A meta-analysis of comparative studies
Li,Wen1,2; Zhou,Fu Chun3; Zhang,Ling3; Ng,Chee H.4; Ungvari,Gabor S.5,6; Li,Jun7; Xiang,Yu Tao1,2
2020-09-01
Source PublicationJournal of Affective Disorders
ISSN0165-0327
Volume274Pages:652-661
AbstractObjective: Cognitive dysfunction is common in both schizophrenia and bipolar disorder. This is a meta-analysis of studies that compared cognitive dysfunction between schizophrenia and bipolar disorder. Methods: Both international and Chinese databases were systematically searched. Studies that compared cognitive function between schizophrenia and bipolar disorder with the MATRICS Consensus Cognitive Battery (MCCB) were analyzed using the random-effects model. Results: Twelve studies with 9,518 participants (4,411 schizophrenia and 5,107 bipolar patients) were included in the analyses. Schizophrenia patients performed significantly worse than bipolar patients on the MCCB total scores with a large effect size (SMD=-0.80, 95%CI: -1.21 to -0.39), as well as on all the 7 subscale scores; attention (SMD=-2.56, 95%CI: -3.55 to -1.57) and social cognition (SMD=-0.86, 95%CI: -1.13 to -0.58) with large effect sizes; and speed of processing (SMD=-0.75, 95%CI: -1.00 to -0.49), working memory (SMD=-0.68, 95%CI: -0.91 to -0.45), verbal learning (SMD=-0.78, 95%CI: -0.95 to -0.61), visual learning (SMD=-0.65, 95%CI: -0.83 to -0.48), and reasoning and problem solving (SMD=-0.61, 95%CI: -0.93 to -0.29) with medium effect sizes. Conclusion: Compared to bipolar patients, patients with schizophrenia had more severe cognitive dysfunction in this meta-analysis, particularly in attention and social cognition. Timely assessment and treatment of cognitive dysfunction should be part of standard management protocols in both schizophrenia and bipolar disorder.
KeywordBipolar disorder Cognition MCCB Meta-analysis Schizophrenia
DOI10.1016/j.jad.2020.04.051
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao SAR,China
2.Center for Cognition and Brain Sciences,University of Macau,Macao SAR,China
3.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,China
4.Department of Psychiatry,The Melbourne Clinic and St Vincent's Hospital,University of Melbourne,Richmond,Australia
5.Division of Psychiatry,School of Medicine,University of Western Australia,Perth,Australia
6.University of Notre Dame Australia,Fremantle,Australia
7.State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research,Beijing Normal University,China
First Author AffilicationFaculty of Health Sciences;  University of Macau
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GB/T 7714
Li,Wen,Zhou,Fu Chun,Zhang,Ling,et al. Comparison of cognitive dysfunction between schizophrenia and bipolar disorder patients: A meta-analysis of comparative studies[J]. Journal of Affective Disorders,2020,274:652-661.
APA Li,Wen,Zhou,Fu Chun,Zhang,Ling,Ng,Chee H.,Ungvari,Gabor S.,Li,Jun,&Xiang,Yu Tao.(2020).Comparison of cognitive dysfunction between schizophrenia and bipolar disorder patients: A meta-analysis of comparative studies.Journal of Affective Disorders,274,652-661.
MLA Li,Wen,et al."Comparison of cognitive dysfunction between schizophrenia and bipolar disorder patients: A meta-analysis of comparative studies".Journal of Affective Disorders 274(2020):652-661.
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