UM
Adjunctive metformin for antipsychotic-induced dyslipidemia: a meta-analysis of randomized, double-blind, placebo-controlled trials
Jiang,Wen Long1; Cai,Dong Bin2; Yin,Fei3; Zhang,Ling4; Zhao,Xi Wu1; He,Jie5; Ng,Chee H.6; Ungvari,Gabor S.7,8; Sim,Kang9; Hu,Mei Ling10; Zheng,Wei11; Xiang,Yu Tao12
2020-12-01
Source PublicationTranslational Psychiatry
Volume10Issue:1
AbstractAntipsychotic-induced dyslipidemia could increase the risk of cardiovascular diseases. This is a meta-analysis of randomized double-blind placebo-controlled trials to examine the efficacy and safety of adjunctive metformin for dyslipidemia induced by antipsychotics in schizophrenia. The standardized mean differences (SMDs) and risk ratios (RRs) with their 95% confidence intervals (CIs) were calculated using the random-effects model with the RevMan 5.3 version software. The primary outcome was the change of serum lipid level. Twelve studies with 1215 schizophrenia patients (592 in metformin group and 623 in placebo group) were included and analyzed. Adjunctive metformin was significantly superior to placebo with regards to low density lipoprotein cholesterol (LDL-C) [SMD: −0.37 (95%CI:−0.69, −0.05), P = 0.02; I = 78%], total cholesterol [SMD: −0.47 (95%CI:−0.66, −0.29), P < 0.00001; I = 49%], triglyceride [SMD: −0.33 (95%CI:−0.45, −0.20), P < 0.00001; I = 0%], and high density lipoprotein cholesterol [SMD: 0.29 (95%CI:0.02, 0.57), P = 0.03; I = 69%]. The superiority of metformin in improving LDL-C level disappeared in a sensitivity analysis and 80% (8/10) of subgroup analyses. Metformin was significantly superior to placebo with regards to decrease in body weight, body mass index, glycated hemoglobin A1c, fasting insulin, and homeostasis model assessment-insulin resistance (P = 0.002–0.01), but not regarding changes in waist circumference, waist-to-hip rate, leptin, fasting glucose, and blood pressure (P = 0.07–0.33). The rates of discontinuation due to any reason [RR: 0.97 (95%CI: 0.66, 1.43), P = 0.89; I = 0%] was similar between the two groups. Adjunctive metformin could be useful to improve total cholesterol and triglyceride levels, but it was not effective in improving LDL-C level in schizophrenia.
DOI10.1038/s41398-020-0785-y
URLView the original
Language英語English
Scopus ID2-s2.0-85083823786
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZheng,Wei
Affiliation1.The Third People’s Hospital of Daqing,Daqing,China
2.Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,China
3.Harbin Medical University Daqing Campus,Daqing,China
4.The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China
5.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection,Capital Medical University,School of Mental Health,Beijing,China
6.Department of Psychiatry,The Melbourne Clinic and St Vincent’s Hospital,University of Melbourne,Richmond,Australia
7.University of Notre Dame Australia,Fremantle,Australia
8.Division of Psychiatry,School of Medicine,University of Western Australia,Perth,Australia
9.West Region,Institute of Mental Health,Buangkok Green Medical Park,Singapore,Singapore
10.The Fifth People’s Hospital of Shangrao,Shangrao,China
11.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital),Guangzhou,China
12.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao
Recommended Citation
GB/T 7714
Jiang,Wen Long,Cai,Dong Bin,Yin,Fei,et al. Adjunctive metformin for antipsychotic-induced dyslipidemia: a meta-analysis of randomized, double-blind, placebo-controlled trials[J]. Translational Psychiatry,2020,10(1).
APA Jiang,Wen Long,Cai,Dong Bin,Yin,Fei,Zhang,Ling,Zhao,Xi Wu,He,Jie,Ng,Chee H.,Ungvari,Gabor S.,Sim,Kang,Hu,Mei Ling,Zheng,Wei,&Xiang,Yu Tao.(2020).Adjunctive metformin for antipsychotic-induced dyslipidemia: a meta-analysis of randomized, double-blind, placebo-controlled trials.Translational Psychiatry,10(1).
MLA Jiang,Wen Long,et al."Adjunctive metformin for antipsychotic-induced dyslipidemia: a meta-analysis of randomized, double-blind, placebo-controlled trials".Translational Psychiatry 10.1(2020).
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