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Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics
Park,Seon Cheol1; Kim,Gyung Mee1; Kato,Takahiro A.2; Chong,Mian Yoon3,4; Lin,Shih Ku5; Yang,Shu Yu6; Avasthi,Ajit7; Grover,Sandeep7; Kallivayalil,Roy Abraham8; Xiang,Yu Tao9; Chee,Kok Yoon10; Tanra,Andi Jayalangkara11; Tan,Chay Hoon12; Sim,Kang13; Sartorius,Norman14; Shinfuku,Naotaka15; Park,Yong Chon16; Inada,Toshiya17
2021
Source PublicationNordic Journal of Psychiatry
ISSN0803-9488
Volume75Issue:1Pages:9-17
AbstractBackground: Network analysis provides a new viewpoint that explicates intertwined and interrelated symptoms into dynamic causal architectures of symptom clusters. This is a process called ‘symptomics’ and is concurrently applied to various areas of symptomatology. Aims: Using the data from Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), we aimed to estimate a network model of extrapyramidal syndrome in patients with schizophrenia. Methods: Using data from REAP-AP, extrapyramidal symptoms of 1046 Asian patients with schizophrenia were evaluated using the nine items of the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). The estimated network of the ordered-categorical DIEPSS items consisted of nodes (symptoms) and edges (interconnections). A community detection algorithm was also used to identify distinctive symptom clusters, and correlation stability coefficients were used to evaluate the centrality stability. Results: An interpretable level of node strength centrality was ensured with a correlation coefficient. An estimated network of extrapyramidal syndrome showed that 26 (72.2%) of all possible 35 edges were estimated to be greater than zero. Dyskinesia was most centrally situated within the estimated network. In addition, earlier antipsychotic-induced extrapyramidal symptoms were divided into three distinctive clusters–extrapyramidal syndrome without parkinsonism, postural instability and gait difficulty-dominant parkinsonism, and tremor-dominant parkinsonism. Conclusions: Our findings showed that dyskinesia is the most central domain in an estimated network structure of extrapyramidal syndrome in Asian patients with schizophrenia. These findings are consistent with the speculation that acute dystonia, akathisia, and parkinsonism could be the risk factors of tardive dyskinesia.
KeywordDrug-Induced Extrapyramidal Symptoms Scale dyskinesia Extrapyramidal syndrome network analysis schizophrenia
DOI10.1080/08039488.2020.1777462
URLView the original
Language英語English
Scopus ID2-s2.0-85087464185
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Psychiatry,Inje University Haeundae Paik Hospital,Busan,South Korea
2.Department of Neuropsychiatry,Graduate School of Medicine,Kyushu University,Fukuoka,Japan
3.Chang Gung Memorial Hospital,Chiayi,Taiwan
4.School of Medicine,Chang Gung University,Kwei-Shan,Taiwan
5.Department of Psychiatry,Taipei City Hospital,Songde Branch,Taipei,Taiwan
6.Department of Pharmacy,Tapei City Hospital,Songde Branch,Tapei,Taiwan
7.Department of Psychiatry,Post Graduate Institute of Medical Education and Research (PGIMER),Chandigarh,India
8.Pushpagiri Institute of Medical Sciences,Tiruvalla,India
9.Center for Cognition and Brain Sciences,University of Macau,Macao
10.Tunku Abdul Rahman Institute of Neuroscience,Kuala Lumpur Hospital,Kuala Lumpur,Malaysia
11.Department of Psychiatry,Faculty of Medicine,Hasanuddin University,Makassar,Indonesia
12.Department of Pharmacology,National University Hospital,Singapore,Singapore
13.West Region,Institute of Mental Health and Yong Loo Lin School of Medicine,National University of Singapore,Singapore
14.Association for the Improvement of Mental Health Programmes,Geneva,Switzerland
15.Department of Social Welfare,School of Human Sciences,Seinan Gakuin University,Fukuoka,Japan
16.Department of Neuropsychiatry,Hanyang University Guri Hospital,Guri,South Korea
17.Department of Psychiatry and Psychobiology,Nagoya University,Graduate School of Medicine,Nagoya,Japan
Recommended Citation
GB/T 7714
Park,Seon Cheol,Kim,Gyung Mee,Kato,Takahiro A.,et al. Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics[J]. Nordic Journal of Psychiatry,2021,75(1):9-17.
APA Park,Seon Cheol,Kim,Gyung Mee,Kato,Takahiro A.,Chong,Mian Yoon,Lin,Shih Ku,Yang,Shu Yu,Avasthi,Ajit,Grover,Sandeep,Kallivayalil,Roy Abraham,Xiang,Yu Tao,Chee,Kok Yoon,Tanra,Andi Jayalangkara,Tan,Chay Hoon,Sim,Kang,Sartorius,Norman,Shinfuku,Naotaka,Park,Yong Chon,&Inada,Toshiya.(2021).Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics.Nordic Journal of Psychiatry,75(1),9-17.
MLA Park,Seon Cheol,et al."Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics".Nordic Journal of Psychiatry 75.1(2021):9-17.
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