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Validation of the 33-item Hypomania Checklist (HCL-33) in screening adolescents with bipolar disorder
Zhang,Yao1; Li,Wen2,3,4; Zhang,Wu Yang1; He,Fan5; Pan,Hong Ping1; Cheung,Teris6; Ungvari,Gabor S.7,8; Li,Shuying1; Xiang,Yu Tao2,3,4; Angst,Jules9
Source PublicationJournal of Affective Disorders

Background: Adolescents with bipolar disorder (BD) are often misdiagnosed with major depressive disorder (MDD), which delays the introduction of appropriate treatment resulting in adverse outcomes. This study examined the psychometric properties of the 33-item Hypomania Checklist (HCL-33) and its accuracy to distinguish BD from MDD in adolescents. Method: A total of 248 participants (171 MDD and 77 BD patients) were recruited from a university-affiliated hospital in China. Depression was measured with the Hamilton Depression Rating Scale. All participants completed the assessment with the HCL-33. Results: A two-factor structure was found for the HCL-33, which explained 30.2% of the total variance. The internal consistency and split half reliability of the total scale were acceptable. The optimal cut-off value of 18 generated sensitivity of 0.52 and specificity of 0.73 for distinguishing BD from MDD. Conclusion: The HCL-33 seems to be a useful screening instrument to distinguish BD from depressed adolescents. However, considering certain less than robust psychometric properties, the HCL-33 needs to be modified and further refined for adolescent patients.

KeywordAdolescents Bipolar Disorder Hcl-33 Major Depressive Disorder Validation
URLView the original
Indexed BySCIE ; SSCI
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000612356400002
Scopus ID2-s2.0-85096542239
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLi,Shuying; Xiang,Yu Tao
Affiliation1.Department of Psychiatry,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,China
2.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao,China
3.Center for Cognition and Brain Sciences,University of Macau,Macao,China
4.Institute of Advanced Studies in Humanities and Social Sciences,University of Macau,Macao,China
5.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection,Capital Medical University,School of Mental Health,China
6.School of Nursing,Hong Kong Polytechnic University,Hong Kong,Hong Kong
7.Division of Psychiatry,School of Medicine,University of Western Australia,Australia
8.University of Notre Dame Australia,Australia
9.Zurich University Psychiatric Hospital,Zurich,Lenggstrasse 31, P.O. Box 1931,8032,Switzerland
Corresponding Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Zhang,Yao,Li,Wen,Zhang,Wu Yang,et al. Validation of the 33-item Hypomania Checklist (HCL-33) in screening adolescents with bipolar disorder[J]. Journal of Affective Disorders,2021,281:786-791.
APA Zhang,Yao,Li,Wen,Zhang,Wu Yang,He,Fan,Pan,Hong Ping,Cheung,Teris,Ungvari,Gabor S.,Li,Shuying,Xiang,Yu Tao,&Angst,Jules.(2021).Validation of the 33-item Hypomania Checklist (HCL-33) in screening adolescents with bipolar disorder.Journal of Affective Disorders,281,786-791.
MLA Zhang,Yao,et al."Validation of the 33-item Hypomania Checklist (HCL-33) in screening adolescents with bipolar disorder".Journal of Affective Disorders 281(2021):786-791.
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