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Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies
Zhao,Na1,2,3; Yang,Yuan1,2,4; Zhang,Ling5; Zhang,Qinge5; Balbuena,Lloyd6; Ungvari,Gabor S.7,8; Zang,Yu Feng3; Xiang,Yu Tao1,2,4
2021-03-01
Source PublicationCNS Neuroscience and Therapeutics
ISSN1755-5930
Volume27Issue:3Pages:270-279
AbstractBackground: Studies regarding the impact of Parkinson's disease (PD) on quality of life (QOL) have reported conflicting results, and the underlying QOL domains require further study. In order to understand the association between PD and QOL, we conducted this meta-analysis to systematically compare QOL between PD patients and healthy controls. Method: The PubMed, PsycINFO, EMBASE, and Web of Science databases were systematically searched. Data were analyzed using the random-effects model. Results: Twenty studies covering 2707 PD patients and 150,661 healthy controls were included in the study. Compared with healthy controls, PD patients had significantly poorer QOL overall and in most domains with moderate to large effects sizes. Different QOL measures varied in their association with quality of life, with the Parkinson's Disease Questionnaire-39 (PDQ-39) having the largest effect size (standard mean difference, SMD = −1.384, 95% CI: −1.607, −1.162, Z = 12.189, P < 0.001), followed by the Europe Quality of Life Questionnaire-visual analogue scale (EQ-VAS) (SMD = −1.081, 95% CI: −1.578, −0.584, Z = −4.265, P < 0.001), Europe Quality of Life Questionnaire-5D (EQ-5D) (SMD = −0.889, 95% CI: −1.181, −0.596, Z = −5.962, P < 0.001), and the Short-form Health Survey (SF) scales (physical dimension: SMD = −0.826, 95% CI: −1.529, −0.123, Z = −2.303, P = 0.021; mental dimension: SMD = −0.376, 95% CI: −0.732, −0.019, Z = −2.064, P = 0.039). Conclusion: PD patients had lower QOL compared with healthy controls in most domains, especially in physical function and mental health. Considering the negative impact of poor QOL on daily life and functional outcomes, effective measures should be developed to improve QOL in this population.
Keywordcomparative study meta-analysis Parkinson's disease quality of life
DOI10.1111/cns.13549
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao
2.Center for Cognition and Brain Sciences,University of Macau,Macao
3.Center for Cognition and Brain Disorders,Institutes of Psychological Sciences,Hangzhou Normal University,Hangzhou,China
4.Institute of Advanced Studies in Humanities and Social Sciences,University of Macau,Macao
5.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & The Advanced Innovation Center for Human Brain Protection,School of Mental Health,Capital Medical University,Beijing,China
6.Department of Psychiatry,University of Saskatchewan,Saskatoon,Canada
7.Division of Psychiatry,School of Medicine,University of Western Australia/Graylands Hospital,Perth,Australia
8.The University of Notre Dame Australia,Fremantle,Australia
First Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Zhao,Na,Yang,Yuan,Zhang,Ling,et al. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies[J]. CNS Neuroscience and Therapeutics,2021,27(3):270-279.
APA Zhao,Na,Yang,Yuan,Zhang,Ling,Zhang,Qinge,Balbuena,Lloyd,Ungvari,Gabor S.,Zang,Yu Feng,&Xiang,Yu Tao.(2021).Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies.CNS Neuroscience and Therapeutics,27(3),270-279.
MLA Zhao,Na,et al."Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies".CNS Neuroscience and Therapeutics 27.3(2021):270-279.
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