UM  > Faculty of Health Sciences
Affiliated with RCfalse
Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies
Zhao,Na1,2,3; Yang,Yuan1,2,4; Zhang,Ling5; Zhang,Qinge5; Balbuena,Lloyd6; Ungvari,Gabor S.7,8; Zang,Yu Feng3; Xiang,Yu Tao1,2,4
Source PublicationCNS Neuroscience and Therapeutics

Background: Studies regarding the impact of Parkinson's disease (PD) on quality of life (QOL) have reported conflicting results, and the underlying QOL domains require further study. In order to understand the association between PD and QOL, we conducted this meta-analysis to systematically compare QOL between PD patients and healthy controls. Method: The PubMed, PsycINFO, EMBASE, and Web of Science databases were systematically searched. Data were analyzed using the random-effects model. Results: Twenty studies covering 2707 PD patients and 150,661 healthy controls were included in the study. Compared with healthy controls, PD patients had significantly poorer QOL overall and in most domains with moderate to large effects sizes. Different QOL measures varied in their association with quality of life, with the Parkinson's Disease Questionnaire-39 (PDQ-39) having the largest effect size (standard mean difference, SMD = −1.384, 95% CI: −1.607, −1.162, Z = 12.189, P < 0.001), followed by the Europe Quality of Life Questionnaire-visual analogue scale (EQ-VAS) (SMD = −1.081, 95% CI: −1.578, −0.584, Z = −4.265, P < 0.001), Europe Quality of Life Questionnaire-5D (EQ-5D) (SMD = −0.889, 95% CI: −1.181, −0.596, Z = −5.962, P < 0.001), and the Short-form Health Survey (SF) scales (physical dimension: SMD = −0.826, 95% CI: −1.529, −0.123, Z = −2.303, P = 0.021; mental dimension: SMD = −0.376, 95% CI: −0.732, −0.019, Z = −2.064, P = 0.039). Conclusion: PD patients had lower QOL compared with healthy controls in most domains, especially in physical function and mental health. Considering the negative impact of poor QOL on daily life and functional outcomes, effective measures should be developed to improve QOL in this population.

KeywordComparative Study Meta-analysis Parkinson's Disease Quality Of Life
URLView the original
Indexed BySCIE ; SSCI
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000603141100001
Scopus ID2-s2.0-85098198583
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang,Yu Tao
Affiliation1.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macao
2.Center for Cognition and Brain Sciences,University of Macau,Macao
3.Center for Cognition and Brain Disorders,Institutes of Psychological Sciences,Hangzhou Normal University,Hangzhou,China
4.Institute of Advanced Studies in Humanities and Social Sciences,University of Macau,Macao
5.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & The Advanced Innovation Center for Human Brain Protection,School of Mental Health,Capital Medical University,Beijing,China
6.Department of Psychiatry,University of Saskatchewan,Saskatoon,Canada
7.Division of Psychiatry,School of Medicine,University of Western Australia/Graylands Hospital,Perth,Australia
8.The University of Notre Dame Australia,Fremantle,Australia
First Author AffilicationFaculty of Health Sciences;  University of Macau
Corresponding Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Zhao,Na,Yang,Yuan,Zhang,Ling,et al. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies[J]. CNS Neuroscience and Therapeutics,2021,27(3):270-279.
APA Zhao,Na,Yang,Yuan,Zhang,Ling,Zhang,Qinge,Balbuena,Lloyd,Ungvari,Gabor S.,Zang,Yu Feng,&Xiang,Yu Tao.(2021).Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies.CNS Neuroscience and Therapeutics,27(3),270-279.
MLA Zhao,Na,et al."Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies".CNS Neuroscience and Therapeutics 27.3(2021):270-279.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao,Na]'s Articles
[Yang,Yuan]'s Articles
[Zhang,Ling]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao,Na]'s Articles
[Yang,Yuan]'s Articles
[Zhang,Ling]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao,Na]'s Articles
[Yang,Yuan]'s Articles
[Zhang,Ling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.