UM  > Faculty of Health Sciences
Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies
Li,Jianzhen1; Ge,Wei2
2020-05-01
Source PublicationMolecular and Cellular Endocrinology
ISSN0303-7207
Volume507
AbstractOvarian development is a complex process controlled by precise coordination of multiple factors. The targeted gene knockout technique is a powerful tool to study the functions of these factors. The successful application of this technique in mice in the past three decades has significantly enhanced our understanding on the molecular mechanism of ovarian development. Recently, with the advent of genome editing techniques, targeted gene knockout research can be carried out in many species. Zebrafish has emerged as an excellent model system to study the control of ovarian development. Dozens of genes related to ovarian development have been knocked out in zebrafish in recent years. Much new information and perspectives on the molecular mechanism of ovarian development have been obtained from these mutant zebrafish. Some findings have challenged conventional views. Several genes have been identified for the first time in vertebrates to control ovarian development. Focusing on ovarian development, the purpose of this review is to briefly summarize recent findings using these gene knockout zebrafish models, and compare these findings with mammalian models. These established mutants and rapid development of gene knockout techniques have prompted zebrafish as an ideal animal model for studying ovarian development.
KeywordCRISPR/Cas9 Gene knockout Germ cell Ovary TALEN Zebrafish ZFN
DOI10.1016/j.mce.2020.110778
URLView the original
Language英语
Scopus ID2-s2.0-85080978473
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLi,Jianzhen
Affiliation1.College of Life Sciences,Northwest Normal University,Lanzhou,730070,China
2.Centre of Reproduction,Development and Aging (CRDA),Faculty of Health Sciences,University of Macau,Taipa,China
Recommended Citation
GB/T 7714
Li,Jianzhen,Ge,Wei. Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies[J]. Molecular and Cellular Endocrinology,2020,507.
APA Li,Jianzhen,&Ge,Wei.(2020).Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies.Molecular and Cellular Endocrinology,507.
MLA Li,Jianzhen,et al."Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies".Molecular and Cellular Endocrinology 507(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li,Jianzhen]'s Articles
[Ge,Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li,Jianzhen]'s Articles
[Ge,Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li,Jianzhen]'s Articles
[Ge,Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.