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Dietary polyphenols for managing cancers: What have we ignored?
Wu,Xu1,2; Li,Mingxing1,2; Xiao,Zhangang1,2; Daglia,Maria3,4; Dragan,Simona5; Delmas,Dominique6; Vong,Chi Teng7; Wang,Yitao7; Zhao,Yueshui1,2; Shen,Jing1,2; Nabavi,Seyed Mohammad8; Sureda,Antoni9,10; Cao,Hui7; Simal-Gandara,Jesus11; Wang,Mingfu12; Sun,Chongde13; Wang,Shengpeng7; Xiao,Jianbo7
2020-07-01
Source PublicationTrends in Food Science and Technology
ISSN0924-2244
Volume101Pages:150-164
Abstract

Although the chemoprevention and anti-cancer activities of dietary polyphenols have been evidenced through both in vitro and in vivo studies, most of the human clinical trials were unsuccessful or even harmful. Debates on the beneficial roles of dietary polyphenols in cancer therapy are increasing. Many dietary polyphenols studies are conducted by in vitro experiments, but the nature of these studies does not consider the complexity of metabolic processes that are present in vivo. These can often cause instability in the dietary polyphenols, thereby leading to unsuccessful extrapolation into animal or human studies. Dietary polyphenols often have low bioavailability, which is mainly due to poor bioaccessibility and significant metabolism mediated by both host enzymes and colon microbiota. Some metabolites or catabolites are more potent and absorb better than the parent component. It is recognised that the oral bioavailability of dietary polyphenols is underestimated when the bioactive metabolites or catabolites are not considered. Notably, dietary polyphenols and their metabolites undergo further cellular metabolism within the cancer cells, which confers “cellular bioavailability” as an additional step to influence the actions of dietary polyphenols. Moreover, there are growing controversies in using dietary polyphenols for both chemopreventive and anti-cancer applications. A clear therapeutic window for dietary polyphenols as specific chemopreventive or chemotherapeutic agents is required. This review, thus, aims to identify key issues that were ignored by most of the studies, or are critical for future investigation.

KeywordAnti-cancer Activity Bioavailability Dietary Polyphenols Metabolites Microbiota Stability
DOI10.1016/j.tifs.2020.05.017
URLView the original
Indexed BySCIE
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000541893100013
Scopus ID2-s2.0-85085570497
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXiao,Jianbo
Affiliation1.Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou,China
2.South Sichuan Institute of Translational Medicine,Luzhou,China
3.Department of Pharmacy,University of Naples Federico II,Naples,Via Domenico Montesano 49,80131,Italy
4.International Research Centre for Food Nutrition and Safety,Jiangsu University,Zhenjiang,212013,China
5.Centre for Interdisciplinary Research & Department of Cardiology,“Victor Babes” University of Medicine and Pharmacy,Timisoara,Romania
6.INSERM Research Centre U1231,Université de Bourgogne Franche-Comté,Dijon,France
7.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
8.Applied Biotechnology Research Centre,Baqiyatallah University Medical Sciences,Tehran,Iran
9.Research Group on Community Nutrition and Oxidative Stress,University of Balearic Islands,Palma de Mallorca,E-07122,Spain
10.CIBEROBN: Fisiopatología de la Obesidad y la Nutrición,Instituto de Salud Carlos III (ISCIII),Spain
11.Nutrition and Bromatology Group,Department of Analytical Chemistry and Food Science,Faculty of Food Science and Technology,University of Vigo - Ourense Campus,Ourense,E-32004,Spain
12.School of Biological Sciences,The University of Hong Kong,Pokfulam Road,Hong Kong
13.Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology,Zhejiang University,Zijingang Campus,Hangzhou,310058,China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu,Xu,Li,Mingxing,Xiao,Zhangang,et al. Dietary polyphenols for managing cancers: What have we ignored?[J]. Trends in Food Science and Technology,2020,101:150-164.
APA Wu,Xu,Li,Mingxing,Xiao,Zhangang,Daglia,Maria,Dragan,Simona,Delmas,Dominique,Vong,Chi Teng,Wang,Yitao,Zhao,Yueshui,Shen,Jing,Nabavi,Seyed Mohammad,Sureda,Antoni,Cao,Hui,Simal-Gandara,Jesus,Wang,Mingfu,Sun,Chongde,Wang,Shengpeng,&Xiao,Jianbo.(2020).Dietary polyphenols for managing cancers: What have we ignored?.Trends in Food Science and Technology,101,150-164.
MLA Wu,Xu,et al."Dietary polyphenols for managing cancers: What have we ignored?".Trends in Food Science and Technology 101(2020):150-164.
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