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In vitro simulated digestion and fecal fermentation of polysaccharides from loquat leaves: Dynamic changes in physicochemical properties and impacts on human gut microbiota
Wu,Ding Tao1; Fu,Yuan1,2; Guo,Huan1,2; Yuan,Qin1; Nie,Xi Rui1; Wang,Sheng Peng3; Gan,Ren You2
2021-01-31
Source PublicationInternational Journal of Biological Macromolecules
ISSN0141-8130
Volume168Pages:733-742
Abstract

The aim of this study was to well understand the dynamic changes of physicochemical properties of polysaccharides from loquat leaves (LLP) during in vitro simulated saliva-gastrointestinal digestion and fecal fermentation and its related impacts on human gut microbiota. Results showed that the contents of reducing sugar of LLP slightly increased during the gastrointestinal digestion, and its molecular weight also slightly decreased, suggesting that LLP could be slightly degraded under the gastrointestinal digestion conditions. Moreover, during the fecal fermentation, the molecular weight of the indigestible LLP (LLP-I) significantly decreased, and the molar ratio of constituent monosaccharides of LLP-I, such as glucuronic acid, galacturonic acid, galactose, and arabinose, significantly changed, indicating that LLP-I could be degraded and consumed by human gut microbiota. Indeed, some beneficial bacteria such as Megasphaera, Megamonas, Bifidobacterium, Phascolarctobacterium, and Desulfovibrio significantly increased, suggesting that LLP-I could change the composition and abundance of gut microbiota. LLP-I could also promote the production of health-promoting short chain fatty acids. Results from this study are benefical to well understand the in vitro digestion and fecal fermentation behaviors of LLP, and LLP can be developed as a potential prebiotic in the functional food industry.

KeywordFecal Fermentation Gut Microbiota In Vitro Digestion Loquat Polysaccharides Structural Characteristic
DOI10.1016/j.ijbiomac.2020.11.130
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000608018200071
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Food Processing and Safety,College of Food Science,Sichuan Agricultural University,Ya'an,625014,China
2.Institute of Urban Agriculture,Chinese Academy of Agricultural Sciences,Chengdu,610213,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
Recommended Citation
GB/T 7714
Wu,Ding Tao,Fu,Yuan,Guo,Huan,et al. In vitro simulated digestion and fecal fermentation of polysaccharides from loquat leaves: Dynamic changes in physicochemical properties and impacts on human gut microbiota[J]. International Journal of Biological Macromolecules,2021,168:733-742.
APA Wu,Ding Tao,Fu,Yuan,Guo,Huan,Yuan,Qin,Nie,Xi Rui,Wang,Sheng Peng,&Gan,Ren You.(2021).In vitro simulated digestion and fecal fermentation of polysaccharides from loquat leaves: Dynamic changes in physicochemical properties and impacts on human gut microbiota.International Journal of Biological Macromolecules,168,733-742.
MLA Wu,Ding Tao,et al."In vitro simulated digestion and fecal fermentation of polysaccharides from loquat leaves: Dynamic changes in physicochemical properties and impacts on human gut microbiota".International Journal of Biological Macromolecules 168(2021):733-742.
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