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Synthesis of carbon onion and its application as a porous carrier for amorphous drug delivery
Miriyala,Nikhila1; Kirby,Daniel J.1; Cumont,Aude2,3; Zhang,Ruoying2,3; Shi,Baogui2; Ouyang,Defang4; Ye,Haitao2,3
2020-04-01
Source PublicationCrystals
Volume10Issue:4
AbstractGiven the great potential of porous carrier-based drug delivery for stabilising the amorphous form of drugs and enhancing dissolution profiles, this work is focussed on the synthesis and application of carbon onion or onion-like carbon (OLC) as a porous carrier for oral amorphous drug delivery, using paracetamol (PA) and ibuprofen (IBU) as model drugs. Annealing of nanodiamonds at 1100 °C produced OLC with a diamond core that exhibited low cytotoxicity on Caco-2 cells. Solution adsorption followed by centrifugation was used for drug loading and results indicated that the initial concentration of drug in the loading solution needs to be kept below 11.5% PA and 20.7% IBU to achieve complete amorphous loading. Also, no chemical interactions between the drug and OLC could be detected, indicating the safety of loading into OLC without changing the chemical nature of the drug. Drug release was complete in the presence of sodium dodecyl sulphate (SDS) and was faster compared to the pure crystalline drug, indicating the potential of OLC as an amorphous drug carrier.
KeywordAdsorption Biocompatibility Biomedical application Nanodiamonds Onion-like carbon
DOI10.3390/cryst10040281
URLView the original
Language英语
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYe,Haitao
Affiliation1.Aston Pharmacy School,School of Life and Health Sciences,Aston University,Birmingham,B4 7ET,United Kingdom
2.School of Engineering and Applied Science,Aston University,Birmingham,B4 7ET,United Kingdom
3.School of Engineering,University of Leicester,Leicester,LE1 7RH,United Kingdom
4.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences (ICMS),University of Macau,Macau,China
Recommended Citation
GB/T 7714
Miriyala,Nikhila,Kirby,Daniel J.,Cumont,Aude,et al. Synthesis of carbon onion and its application as a porous carrier for amorphous drug delivery[J]. Crystals,2020,10(4).
APA Miriyala,Nikhila,Kirby,Daniel J.,Cumont,Aude,Zhang,Ruoying,Shi,Baogui,Ouyang,Defang,&Ye,Haitao.(2020).Synthesis of carbon onion and its application as a porous carrier for amorphous drug delivery.Crystals,10(4).
MLA Miriyala,Nikhila,et al."Synthesis of carbon onion and its application as a porous carrier for amorphous drug delivery".Crystals 10.4(2020).
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