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Design, synthesis and anti-platelet aggregation activity study of ginkgolide-1,2,3-triazole derivatives
Cui,Jian1; Hu,Lean1,2; Shi,Wei3; Cui,Guozhen3; Zhang,Xumu2; Zhang,Qing Wen1
2019-06-07
Source PublicationMolecules
Volume24Issue:11
AbstractGinkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules. A series of ginkgolide-1,2,3-triazole conjugates with varied functional groups including benzyl, phenyl and heterocycle moieties was thus synthesized. Many of the designed derivatives showed potent antiplatelet aggregation activities with IC values of 5~21 nM.
KeywordGinkgolide Inhibitor Platelet-activating factor receptor
DOI10.3390/molecules24112156
URLView the original
Language英语
Scopus ID2-s2.0-85067233941
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorCui,Guozhen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,999078,Macao
2.Department of Chemistry,Shenzhen Grubbs Institute,Southern University of Science and Technology,Shenzhen,518000,China
3.Department of Bioengineering,Zhuhai Campus of Zunyi Medical University,Guangdong, Zhuhai,519041,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cui,Jian,Hu,Lean,Shi,Wei,et al. Design, synthesis and anti-platelet aggregation activity study of ginkgolide-1,2,3-triazole derivatives[J]. Molecules,2019,24(11).
APA Cui,Jian,Hu,Lean,Shi,Wei,Cui,Guozhen,Zhang,Xumu,&Zhang,Qing Wen.(2019).Design, synthesis and anti-platelet aggregation activity study of ginkgolide-1,2,3-triazole derivatives.Molecules,24(11).
MLA Cui,Jian,et al."Design, synthesis and anti-platelet aggregation activity study of ginkgolide-1,2,3-triazole derivatives".Molecules 24.11(2019).
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