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Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy
Men,Xiaoju1; Chen,Haobin2; Sun,Chen3; Liu,Yubin1; Wang,Ruibing3; Zhang,Xuanjun1; Wu,Changfeng2; Yuan,Zhen1
2020-11-18
Source PublicationACS Applied Materials and Interfaces
ISSN1944-8244
Volume12Issue:46Pages:51174-51184
Abstract

Precision delivery of theranostic agents to the tumor site is essential to improve their diagnostic and therapeutic efficacy and concurrently minimize adverse effects during treatment. In this study, a novel concept of near-infrared (NIR) light activation of conjugated polymer dots (Pdots) at thermosensitive hydrogel nanostructures is introduced for multimodal imaging-guided synergistic chemo-photothermal therapy. Interestingly, owing to the attractive photothermal conversion efficiency of Pdots, the Pdots@hydrogel as theranostic agents is able to undergo a controllable softening or melting state under the irradiation of NIR laser, resulting in light-triggered drug release in a controlled way and concurrently hydrogel degradation. Besides, the novel Pdots@hydrogel nanoplatform can serve as the theranostic agent for enhanced trimodal photoacoustic (PA)/computed tomography (CT)/fluorescence (FL) imaging-guided synergistic chemo-photothermal therapy of tumors. More importantly, the constructed intelligent nanocomposite Pdots@hydrogel exhibits excellent biodegradability, strong NIR absorption, bright PA/CT/FL signals, and superior tumor ablation effect. Therefore, the concept of a light-controlled multifunctional Pdots@hydrogel that integrates multiple diagnostic/therapeutic modalities into one nanoplatform can potentially be applied as a smart nanotheranostic agent to various perspectives of personalized nanomedicine.

KeywordChemo-photothermal Therapy Controlled Drug Release Multimode Imaging Photoacoustic Imaging Semiconducting Polymer Nanoparticles
DOI10.1021/acsami.0c13252
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000592923100004
Scopus ID2-s2.0-85096456767
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYuan,Zhen
Affiliation1.Faculty of Health Sciences,Center for Cognitive and Brain Sciences,University of Macau,Taipa Macau SAR,999708,Macao
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen Guangdong,518055,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa Macau SAR,999708,Macao
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Men,Xiaoju,Chen,Haobin,Sun,Chen,et al. Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy[J]. ACS Applied Materials and Interfaces,2020,12(46):51174-51184.
APA Men,Xiaoju,Chen,Haobin,Sun,Chen,Liu,Yubin,Wang,Ruibing,Zhang,Xuanjun,Wu,Changfeng,&Yuan,Zhen.(2020).Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy.ACS Applied Materials and Interfaces,12(46),51174-51184.
MLA Men,Xiaoju,et al."Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy".ACS Applied Materials and Interfaces 12.46(2020):51174-51184.
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