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Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy
Yang,Kuikun1,2; Yu,Guocan2; Tian,Rui2; Zhou,Zijian2; Deng,Hongzhang2; Li,Ling2; Yang,Zhen2; Zhang,Guofeng2; Liu,Dahai2; Wei,Jianwen1; Yue,Ludan1; Wang,Ruibing1; Chen,Xiaoyuan3
Source PublicationAdvanced Functional Materials

Immunological tolerance induced by the hypoxic tumor microenvironment has been a major challenge for current immune checkpoint blockade therapies. Here, a hypoxia-responsive drug delivery nanoplatform is reported to promote chemoimmunotherapy of cancer by overcoming the hypoxia-induced immunological tolerance of tumors. The nanovesicles are assembled from manganese ferrite nanoparticles (MFNs) grafted with hypoxia-responsive amphiphilic polymers as the membrane, with doxorubicin hydrochloride (Dox) loaded in the aqueous cavities. Under hypoxic conditions in tumors, the nanovesicles can rapidly dissociate into individual MFNs to release Dox and induce decomposition of tumor endogenous HO for tumor hypoxia relief. As a result, the Dox-loaded nanovesicles display remarkable suppression of primary tumor growth in combination with αPD-L1-mediated checkpoint blockade therapy. Furthermore, the modulation of the hypoxic tumor microenvironment facilitates a long-lasting immunological memory effect to prevent tumor recurrence and metastasis. Therefore, this hypoxia-responsive nanoplatform presents a potential strategy for both local tumor treatment and long-term protection against tumor recurrence.

KeywordChemoimmunotherapy Drug Delivery Hypoxia-responsive Self-assembly
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000608837800001
Scopus ID2-s2.0-85100169318
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorDeng,Hongzhang; Wang,Ruibing; Chen,Xiaoyuan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Avenida da Universidade,999078,Macao
2.Laboratory of Molecular Imaging and Nanomedicine,National Institute of Biomedical Imaging and Bioengineering,National Institutes of Health Bethesda,Bethesda,20892,United States
3.Yong Loo Lin School of Medicine,Faculty of Engineering,National University of Singapore,Singapore,119228,Singapore
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Yang,Kuikun,Yu,Guocan,Tian,Rui,et al. Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy[J]. Advanced Functional Materials,2021,31(11).
APA Yang,Kuikun,Yu,Guocan,Tian,Rui,Zhou,Zijian,Deng,Hongzhang,Li,Ling,Yang,Zhen,Zhang,Guofeng,Liu,Dahai,Wei,Jianwen,Yue,Ludan,Wang,Ruibing,&Chen,Xiaoyuan.(2021).Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy.Advanced Functional Materials,31(11).
MLA Yang,Kuikun,et al."Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy".Advanced Functional Materials 31.11(2021).
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