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Research progress on effects of indirubin and its structurally similar compounds on anticancer and neuroprotection
Wang,Ying1,2; Sa,Fei1,2; Chan,Yuet Wa1,2; Lee,Ming Yuen1,2
2014-08-28
Source PublicationChinese Traditional and Herbal Drugs
ISSN0253-2670
Volume45Issue:16Pages:2404-2411
AbstractIndirubin is the active ingredient in many Chinese materia medica and mainly used to treat leukemia. It has been founded as leading inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. Increasing new findings pointed out that the unique chemical structure of indirubin could contribute to the polypharmacological activities particularly against cancer and neurodegeneration therapy while these diseases shared common molecular link on abnormal phosphorylation of CDKs and GSK-3. In this review, the underlying mechanisms of dual actions of indirubin and its structurally similar compounds on therapy of cancer and neurodegenerative diseases are presented.
KeywordAnticancer Cyclin-dependent kinases Glycogen synthase kinase-3 Indirubin Neurodegeneration disease
DOI10.7501/j.issn.0253-2670.2014.16.024
URLView the original
Language英语
Scopus ID2-s2.0-84921500544
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau,Macao
2.Institute of Chinese Medical Sciences, University of Macau,Macao
First Author AffilicationUniversity of Macau;  Institute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang,Ying,Sa,Fei,Chan,Yuet Wa,et al. Research progress on effects of indirubin and its structurally similar compounds on anticancer and neuroprotection[J]. Chinese Traditional and Herbal Drugs,2014,45(16):2404-2411.
APA Wang,Ying,Sa,Fei,Chan,Yuet Wa,&Lee,Ming Yuen.(2014).Research progress on effects of indirubin and its structurally similar compounds on anticancer and neuroprotection.Chinese Traditional and Herbal Drugs,45(16),2404-2411.
MLA Wang,Ying,et al."Research progress on effects of indirubin and its structurally similar compounds on anticancer and neuroprotection".Chinese Traditional and Herbal Drugs 45.16(2014):2404-2411.
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