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Transforming the spleen into a liver-like organ in vivo
Wang,Lintao1,2; Wang,Chunming2; Wang,Zhenzhen1,2; Gan,Jingjing1; Liu,Chunyan1; Xia,Suhua3; Niu,Yiming2; Chen,Dianhua1; Zhang,Junfeng1; Dong,Lei1,4
2020-06-01
Source PublicationScience Advances
Volume6Issue:24
Abstract

Regenerating human organs remains an unmet medical challenge. Suitable transplants are scarce, while engineered tissues have a long way to go toward clinical use. Here, we demonstrate a different strategy that successfully transformed an existing, functionally dispensable organ to regenerate another functionally vital one in the body. Specifically, we injected a tumor extract into the mouse spleen to remodel its tissue structure into an immunosuppressive and proregenerative microenvironment. We implanted autologous, allogeneic, or xenogeneic liver cells (either primary or immortalized), which survived and proliferated in the remodeled spleen, without exerting adverse responses. Notably, the allografted primary liver cells exerted typical hepatic functions to rescue the host mice from severe liver damages including 90% hepatectomy. Our approach shows its competence in overcoming the key challenges in tissue regeneration, including insufficient transplants, immune rejection, and poor vascularization. It may be ready for translation into new therapies to regenerate large, complex human tissue/organs.

DOI10.1126/sciadv.aaz9974
URLView the original
Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000542291800024
Scopus ID2-s2.0-85086505336
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang,Chunming
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,163 Xianlin Avenue,210093,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa, Macau SAR,Macao
3.Department of Oncology,First Affiliated Hospital of Soochow University,Suzhou,215006,China
4.Chemistry and Biomedicine Innovative Center,Nanjing University,Nanjing,163 Xianlin Avenue,210093,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang,Lintao,Wang,Chunming,Wang,Zhenzhen,et al. Transforming the spleen into a liver-like organ in vivo[J]. Science Advances,2020,6(24).
APA Wang,Lintao,Wang,Chunming,Wang,Zhenzhen,Gan,Jingjing,Liu,Chunyan,Xia,Suhua,Niu,Yiming,Chen,Dianhua,Zhang,Junfeng,&Dong,Lei.(2020).Transforming the spleen into a liver-like organ in vivo.Science Advances,6(24).
MLA Wang,Lintao,et al."Transforming the spleen into a liver-like organ in vivo".Science Advances 6.24(2020).
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