UM
Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches
Niu,Yiming1,2; Wang,Zhenzhen1,2; Shi,Yuchen1; Dong,Lei2; Wang,Chunming1
2021
Source PublicationBioactive Materials
ISSN2452-199X
Volume6Issue:1Pages:244-261
AbstractA coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone healing. In particular, macrophages play a central regulatory role in all stages of bone repair. Depending on the signals they sense, these highly plastic cells can mediate the host immune response against the exterior signals of molecular stimuli and implanted scaffolds, to exert regenerative potency to a varying extent. In this article, we first encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects, as sweeper, mediator and instructor. We introduce the phagocytic role of macrophages in different bone healing periods (‘sweeper’) and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation, vascularisation and matrix remodelling (‘mediator’), or directly driving the osteogenic differentiation of bone progenitors and bone repair (‘instructor’). Then, we systematically classify and discuss the emerging engineering strategies to recruit, activate and modulate the phenotype transition of macrophages, to exploit the power of endogenous macrophages to enhance the performance of engineered bone tissue.
KeywordBiomaterial-host interaction Bone regeneration Inflammation Macrophages Phenotype transition
DOI10.1016/j.bioactmat.2020.08.012
URLView the original
Language英语
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorWang,Chunming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Avenida da Universidade,Macau SAR,China
2.State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,210093,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Niu,Yiming,Wang,Zhenzhen,Shi,Yuchen,et al. Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches[J]. Bioactive Materials,2021,6(1):244-261.
APA Niu,Yiming,Wang,Zhenzhen,Shi,Yuchen,Dong,Lei,&Wang,Chunming.(2021).Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches.Bioactive Materials,6(1),244-261.
MLA Niu,Yiming,et al."Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches".Bioactive Materials 6.1(2021):244-261.
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