UM
20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse
Guo,Wen Qin1; Chen,Ying Ge1; Shi,Rong Zhen1; He,Kai2; Wang,Jian Feng1; Shao,Jin Hui1; Wan,Jian Bo3; Gao,Jian Li1
2020
Source PublicationEvidence-based Complementary and Alternative Medicine
ISSN1741-427X
Volume2020
AbstractPanax notoginseng (PN) has been used as a qi- and blood-activating (Huoxue) drug for thousands of years in China. It has also been widely used as an anticancer drug at present. As a Huoxue drug, the effect of PN on hematopoietic differentiation in tumor-bearing body has been paid more and more attention. Our research found that panax notoginseng saponins (PNS), especially panaxadiol saponins (PDS) and its aglucon 20(S)-Protopanaxdiol (PPD), could improve the immunosuppressive state by regulating the abnormal hematopoietic differentiation in a tumor-bearing body by multiple ways. An interesting phenomenon is that PDS reduced the neutrophil-lymphocyte ratio (NLR) via its inhibition effect on the granule-monocyte differentiation of spleen cells, which is associated with a decrease in the secretion of tumor MPO, G-CSF, PU.1, and C/EBPα. Otherwise, PDS increased the proportion of both hematopoietic stem cells and erythroid progenitor cells in the bone marrow, but inhibited spleen erythroid differentiation via inhibiting secretion of tumor EPO, GATA-1, and GATA-2. This study suggests that PNS regulated the tumor-induced abnormal granule-monocyte differentiation of hematopoietic stem cells, affecting the distribution and function of haemocytes in tumor-bearing mice.
DOI10.1155/2020/8747023
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Zhejiang Chinese Medical University,Hangzhou, Zhejiang,310053,China
2.First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou, Zhejiang,310009,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
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GB/T 7714
Guo,Wen Qin,Chen,Ying Ge,Shi,Rong Zhen,et al. 20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse[J]. Evidence-based Complementary and Alternative Medicine,2020,2020.
APA Guo,Wen Qin,Chen,Ying Ge,Shi,Rong Zhen,He,Kai,Wang,Jian Feng,Shao,Jin Hui,Wan,Jian Bo,&Gao,Jian Li.(2020).20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.Evidence-based Complementary and Alternative Medicine,2020.
MLA Guo,Wen Qin,et al."20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse".Evidence-based Complementary and Alternative Medicine 2020(2020).
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