UM
Regulation of CD47 expression in cancer cells
Huang,Can Yu; Ye,Zi Han; Huang,Mu Yang; Lu,Jin Jian
2020-12-01
Source PublicationTranslational Oncology
Volume13Issue:12
AbstractCD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance. Targeting the phagocytosis checkpoint of CD47-SIRPα axis has shown remarkable anticancer effect in preclinical and clinical research, which indicates the potential application of CD47-SIRPα blockade for cancer treatment. In this case, the comprehensive description of the regulation of CD47 in different types of cancer cells has significant implications for furthering our understanding of the role of CD47 in cancer. Based on the current reports, we summarized the regulatory factors, i.e., cytokines, oncogenes, microRNAs as well as enzymes, of CD47 expression in cancer cells. Accordingly, we also proposed several points needing further research, hoping to provide useful insights for the future investigation on the regulation of CD47 in cancers.
KeywordCD47 Cytokine MicroRNA Oncogene QPCTL
DOI10.1016/j.tranon.2020.100862
URLView the original
Language英语
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang,Can Yu,Ye,Zi Han,Huang,Mu Yang,et al. Regulation of CD47 expression in cancer cells[J]. Translational Oncology,2020,13(12).
APA Huang,Can Yu,Ye,Zi Han,Huang,Mu Yang,&Lu,Jin Jian.(2020).Regulation of CD47 expression in cancer cells.Translational Oncology,13(12).
MLA Huang,Can Yu,et al."Regulation of CD47 expression in cancer cells".Translational Oncology 13.12(2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang,Can Yu]'s Articles
[Ye,Zi Han]'s Articles
[Huang,Mu Yang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang,Can Yu]'s Articles
[Ye,Zi Han]'s Articles
[Huang,Mu Yang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang,Can Yu]'s Articles
[Ye,Zi Han]'s Articles
[Huang,Mu Yang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.