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Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics
Zhang,Le Le1; Huang,Mu Yang2; Yang,Yong1; Huang,Ming Qing3; Shi,Jia Jie2; Zou,Liang1; Lu,Jin Jian2,4
2020-10-15
Source PublicationFood Chemistry
ISSN0308-8146
Volume327
Abstract

Platycodonis Radix, the root of Platycodon grandiflorum (Jacq.) A. DC., is a well-known edible herbal medicine. It is a common vegetable used for the preparation of side dish, kimchi, dessert, and tea. Besides, it has been used to treat respiratory disease including cough, excessive phlegm, and sore throat for a long history. In the past decades, the bioactive components and the pharmacological activities of Platycodonis Radix have been widely investigated. Thereinto, platycodins, the oleanane-type triterpenoid saponins were demonstrated to be the main bioactive components in Platycodonis Radix, and more than 70 platycodins have been identified up to date. This paper mainly reviewed the phytochemistry, pharmacological activities (apophlegmatic, anti-tussive, anti-inflammatory, anti-cancer, anti-obesity, anti-diabetic, immunomodulatory, cardiovascular protective, and hepatoprotective activities, etc.), toxicology and pharmacokinetics of platycodins isolated from Platycodonis Radix, aiming to promote further investigation on therapeutic potential of these platycodins.

KeywordPharmacokinetics Pharmacological Activities Phytochemistry Platycodins Platycodonis Radix Toxicology
DOI10.1016/j.foodchem.2020.127029
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000538575800022
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZou,Liang
Affiliation1.School of Medicine,Chengdu University,Chengdu,610106,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,999078,Macao
3.College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,350122,China
4.College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China
Recommended Citation
GB/T 7714
Zhang,Le Le,Huang,Mu Yang,Yang,Yong,et al. Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics[J]. Food Chemistry,2020,327.
APA Zhang,Le Le,Huang,Mu Yang,Yang,Yong,Huang,Ming Qing,Shi,Jia Jie,Zou,Liang,&Lu,Jin Jian.(2020).Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics.Food Chemistry,327.
MLA Zhang,Le Le,et al."Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics".Food Chemistry 327(2020).
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