Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease
Zhu,Zhou1; Yang,Chuanbin1; Iyaswamy,Ashok1; Krishnamoorthi,Senthilkumar1; Sreenivasmurthy,Sravan Gopalkrishnashetty1; Liu,Jia1; Wang,Ziying1; Tong,Benjamin Chun Kit1; Song,Juxian2; Lu,Jiahong3; Cheung,King Ho1; Li,Min1
Source PublicationInternational Journal of Molecular Sciences
AbstractThe mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson’s disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development.
KeywordAutophagy mTOR Parkinson’s disease
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLi,Min
Affiliation1.Ko Chi Ming Centre for Parkinson’s Disease Research,School of Chinese Medicine,Hong Kong Baptist University,999077,Hong Kong
2.Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou,510006,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,999078,Macao
Recommended Citation
GB/T 7714
Zhu,Zhou,Yang,Chuanbin,Iyaswamy,Ashok,et al. Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease[J]. International Journal of Molecular Sciences,2019,20(3).
APA Zhu,Zhou,Yang,Chuanbin,Iyaswamy,Ashok,Krishnamoorthi,Senthilkumar,Sreenivasmurthy,Sravan Gopalkrishnashetty,Liu,Jia,Wang,Ziying,Tong,Benjamin Chun Kit,Song,Juxian,Lu,Jiahong,Cheung,King Ho,&Li,Min.(2019).Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease.International Journal of Molecular Sciences,20(3).
MLA Zhu,Zhou,et al."Balancing mTOR signaling and autophagy in the treatment of Parkinson’s disease".International Journal of Molecular Sciences 20.3(2019).
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