High content screening for drug discovery from traditional Chinese medicine
Wang,Jing1; Wu,Ming Yue1; Tan,Jie Qiong2; Li,Min3; Lu,Jia Hong1
Source PublicationChinese Medicine (United Kingdom)
AbstractTraditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved efficacy in human diseases and abundant biologically active components pools. To dissect the mystery of TCM, modern technologies such as omics approaches (proteomics, genomics, metabolomics) and drug screening technologies (high through-put screening, high content screening and virtual screening) have been widely applied to either identify the drug target of TCM or identify the active component with certain bio-activity. The advent of high content screening technology has absolutely contributed to a breakthrough in compounds discovery and influenced the evolution of technology in screening field. The review introduces the concept and principle of high content screening, lists and compares the currently used HCS instruments, and summarizes the examples from ours and others research work which applied HCS in TCM-derived compounds screening. Meanwhile, this article also discusses the advantages and limitations of HSC technology in drug discovery from TCM libraries.
KeywordAdvanced models Drug discovery High-content screening Progressive instruments Traditional Chinese medicine
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.Key Laboratory of Medical Genetics,Xiangya Medical School,Central South University,Changsha, Hunan,China
3.Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong SAR,Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang,Jing,Wu,Ming Yue,Tan,Jie Qiong,et al. High content screening for drug discovery from traditional Chinese medicine[J]. Chinese Medicine (United Kingdom),2019,14(1).
APA Wang,Jing,Wu,Ming Yue,Tan,Jie Qiong,Li,Min,&Lu,Jia Hong.(2019).High content screening for drug discovery from traditional Chinese medicine.Chinese Medicine (United Kingdom),14(1).
MLA Wang,Jing,et al."High content screening for drug discovery from traditional Chinese medicine".Chinese Medicine (United Kingdom) 14.1(2019).
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