Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
Wu,Ming Yue; Lu,Jia Hong
Source PublicationCells
AbstractAutophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regulating inflammatory responses. During the past two decades, accumulated evidence has revealed the intrinsic connection between autophagy and macrophage function. This review focuses on the role of autophagy, both as nonselective and selective forms, in the regulation of the inflammatory and phagocytotic functions of macrophages. Specifically, the roles of autophagy in pattern recognition, cytokine release, inflammasome activation, macrophage polarization, LC3-associated phagocytosis, and xenophagy are comprehensively reviewed. The roles of autophagy receptors in the macrophage function regulation are also summarized. Finally, the obstacles and remaining questions regarding the molecular regulation mechanisms, disease association, and therapeutic applications are discussed.
Keywordautophagy inflammatory response macrophage phagocytosis
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Wu,Ming Yue,Lu,Jia Hong. Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis[J]. Cells,2019,9(1).
APA Wu,Ming Yue,&Lu,Jia Hong.(2019).Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis.Cells,9(1).
MLA Wu,Ming Yue,et al."Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis".Cells 9.1(2019).
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