UM
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review
Wang,Zi Ying1,5; Liu,Jia1; Zhu,Zhou1; Su,Cheng Fu1; Sreenivasmurthy,Sravan Gopalkrishnashetty1; Iyaswamy,Ashok1; Lu,Jia Hong2; Chen,Gang4,5; Song,Ju Xian1,3; Li,Min1
2021
Source PublicationBiomedicine and Pharmacotherapy
ISSN0753-3322
Volume133
AbstractNeurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
KeywordAutophagy Neurodegenerative disease Neuroprotection Traditional Chinese medicine
DOI10.1016/j.biopha.2020.110968
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research,School of Chinese Medicine,Hong Kong Baptist University,Hong Kong
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau SAR,China
3.Medical College of Acupuncture-Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou,China
4.Co-innovation Center of Neuroregeneration,Nantong University,Nantong,China
5.Interdisciplinary Institute for Personalized Medicine in Brain Disorders,Jinan University,Guangzhou,China
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GB/T 7714
Wang,Zi Ying,Liu,Jia,Zhu,Zhou,et al. Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review[J]. Biomedicine and Pharmacotherapy,2021,133.
APA Wang,Zi Ying.,Liu,Jia.,Zhu,Zhou.,Su,Cheng Fu.,Sreenivasmurthy,Sravan Gopalkrishnashetty.,...&Li,Min.(2021).Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review.Biomedicine and Pharmacotherapy,133.
MLA Wang,Zi Ying,et al."Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review".Biomedicine and Pharmacotherapy 133(2021).
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