UM  > Institute of Chinese Medical Sciences
Coptidis rhizoma and its main bioactive components: Recent advances in chemical investigation, quality evaluation and pharmacological activity
Meng,Fan Cheng1; Wu,Zheng Feng1; Yin,Zhi Qi2; Lin,Li Gen1; Wang,Ruibing1; Zhang,Qing Wen1
2018-03-07
Source PublicationChinese Medicine (United Kingdom)
Volume13Issue:1
AbstractBackground: Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment of various diseases including bacillary dysentery, typhoid, tuberculosis, epidemic cerebrospinal meningitis, empyrosis, pertussis, and other illnesses. Methods: A literature survey was conducted via SciFinder, ScieneDirect, PubMed, Springer, and Wiley databases. A total of 139 selected references were classified on the basis of their research scopes, including chemical investigation, quality evaluation and pharmacological studies. Results: Many types of secondary metabolites including alkaloids, lignans, phenylpropanoids, flavonoids, phenolic compounds, saccharides, and steroids have been isolated from CR. Among them, protoberberine-type alkaloids, such as berberine, palmatine, coptisine, epiberberine, jatrorrhizine, columamine, are the main components of CR. Quantitative determination of these alkaloids is a very important aspect in the quality evaluation of CR. In recent years, with the advances in isolation and detection technologies, many new instruments and methods have been developed for the quantitative and qualitative analysis of the main alkaloids from CR. The quality control of CR has provided safety for pharmacological applications. These quality evaluation methods are also frequently employed to screen the active components from CR. Various investigations have shown that CR and its main alkaloids exhibited many powerful pharmacological effects including anti-inflammatory, anti-cancer, anti-diabetic, neuroprotective, cardioprotective, hypoglycemic, anti-Alzheimer and hepatoprotective activities. Conclusion: This review summarizes the recent phytochemical investigations, quality evaluation methods, the biological studies focusing on CR as well as its main alkaloids.
KeywordCoptidis rhizoma Coptis genus Pharmacological effects Phytochemistry Quality evaluation
DOI10.1186/s13020-018-0171-3
URLView the original
Language英语
Scopus ID2-s2.0-85043353651
Fulltext Access
Citation statistics
Cited Times [WOS]:63   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang,Ruibing
Affiliation1.University of Macau,State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,Macao,Macao
2.China Pharmaceutical University,Department of Traditional Chinese Medicines Pharmaceuticals,Nanjing,210009,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Meng,Fan Cheng,Wu,Zheng Feng,Yin,Zhi Qi,et al. Coptidis rhizoma and its main bioactive components: Recent advances in chemical investigation, quality evaluation and pharmacological activity[J]. Chinese Medicine (United Kingdom),2018,13(1).
APA Meng,Fan Cheng,Wu,Zheng Feng,Yin,Zhi Qi,Lin,Li Gen,Wang,Ruibing,&Zhang,Qing Wen.(2018).Coptidis rhizoma and its main bioactive components: Recent advances in chemical investigation, quality evaluation and pharmacological activity.Chinese Medicine (United Kingdom),13(1).
MLA Meng,Fan Cheng,et al."Coptidis rhizoma and its main bioactive components: Recent advances in chemical investigation, quality evaluation and pharmacological activity".Chinese Medicine (United Kingdom) 13.1(2018).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Meng,Fan Cheng]'s Articles
[Wu,Zheng Feng]'s Articles
[Yin,Zhi Qi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Meng,Fan Cheng]'s Articles
[Wu,Zheng Feng]'s Articles
[Yin,Zhi Qi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Meng,Fan Cheng]'s Articles
[Wu,Zheng Feng]'s Articles
[Yin,Zhi Qi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.