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Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation
Li,Dan1,2; Zhang,Tian2; Lu,Jinjian2; Peng,Cheng1; Lin,Ligen2
2021-10
Source PublicationCritical Reviews in Food Science and Nutrition
ISSN1040-8398
Volume61Issue:12Pages:1947-1965
Abstract

Adipose tissue, an endocrine and paracrine organ, plays critical roles in the regulation of whole-body metabolic homeostasis. Obesity is accompanied with a chronic low-grade inflammation status in adipose tissue, which disrupts its endocrine function and results in metabolic derangements, such as type 2 diabetes. Dietary bioactive components, such as flavonoids, polyphenols and unsaturated fatty acids from fruits and vegetables, have been widely revealed to alleviate both systemic and adipose tissue inflammation, and improve metabolic disorders. Remarkably, some dietary bioactive components mitigate the inflammatory response in adipocytes, macrophages, and other immune cells, and modulate the crosstalk between adipocytes and macrophages or other immune cells, in adipose tissue. Epidemiological and preclinical studies related to these substances have indicated beneficial effects on adipose tissue inflammation. The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge on dietary components targeting adipose tissue inflammation and their underlying mechanisms. These natural products have great potential to be developed as functional food or lead compounds for treating and/or preventing metabolic disorders.

KeywordAdipocytes Adipose Tissue Inflammation Crosstalk Dietary Bioactive Nutrients Macrophages Metabolic Disease
DOI10.1080/10408398.2020.1768044
URLView the original
Indexed BySCIE
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000541285700001
Scopus ID2-s2.0-85086322163
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorPeng,Cheng; Lin,Ligen
Affiliation1.State Key Laboratory of Southwestern Characteristic Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li,Dan,Zhang,Tian,Lu,Jinjian,et al. Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation[J]. Critical Reviews in Food Science and Nutrition,2021,61(12):1947-1965.
APA Li,Dan,Zhang,Tian,Lu,Jinjian,Peng,Cheng,&Lin,Ligen.(2021).Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation.Critical Reviews in Food Science and Nutrition,61(12),1947-1965.
MLA Li,Dan,et al."Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation".Critical Reviews in Food Science and Nutrition 61.12(2021):1947-1965.
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