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Anti-inflammatory property of the essential oil from cinnamomum camphora (Linn.) presl leaves and the evaluation of its underlying mechanism by using metabolomics analysis
Chen,Jiali1,2; Tang,Cailin1; Zhou,Yang1; Zhang,Rongfei1; Ye,Shaoxia1; Zhao,Zhimin1; Lin,Ligen2; Yang,Depo1
2020-10-01
Source PublicationMolecules
Volume25Issue:20
AbstractCinnamomum camphora (Linn.) Presl has been widely used in traditional Chinese medicine for a variety of purposes. Our previous study indicated the antibacterial mechanism of the essential oil (EO) from C. camphora leaves; however, its anti-inflammatory activity and the underlying mechanism have not been clearly demonstrated. Thus, the present study investigated its anti-inflammatory property. Our data revealed that EO significantly decreased the release of nitric oxide (NO) and the mRNA expression of inducible NO synthase (iNOS) in lipopolysaccharide (LPS)-induced BV2 microglial cells. EO also attenuated LPS-induced increase in the mRNA expression and secretion of inflammatory cytokines including interleukin-6 (IL-6), IL-18, IL-1β and tumor necrosis factor-α (TNF-α). Furthermore, the metabolic profiles of LPS-induced BV2 microglial cells treated with or without EO were explored. Thirty-nine metabolites were identified with significantly different contents, including 21 upregulated and 18 downregulated ones. Five pathways were enriched by shared differential metabolites. Compared with the control cells, the glucose level was decreased, while the lactate level was increased, in the culture supernatant from LPS-stimulated cells, which were reversed by EO treatment. Moreover, compared to the LPS-treated group, the activities of phosphofructokinase (PFK) and pyruvate kinase (PK) in EO group were decreased. In summary, the current study demonstrated that EO from C. camphora leaves acts as an anti-inflammatory agent, which might be mediated through attenuating the glycolysis capacity of microglial cells.
KeywordAnti-inflammation BV2 microglial cells Cinnamomum camphora (Linn.) Presl Essential oil Glycolysis Metabolomics
DOI10.3390/molecules25204796
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLin,Ligen
Affiliation1.School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou,510006,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Avenida da Universidade,999078,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Chen,Jiali,Tang,Cailin,Zhou,Yang,et al. Anti-inflammatory property of the essential oil from cinnamomum camphora (Linn.) presl leaves and the evaluation of its underlying mechanism by using metabolomics analysis[J]. Molecules,2020,25(20).
APA Chen,Jiali,Tang,Cailin,Zhou,Yang,Zhang,Rongfei,Ye,Shaoxia,Zhao,Zhimin,Lin,Ligen,&Yang,Depo.(2020).Anti-inflammatory property of the essential oil from cinnamomum camphora (Linn.) presl leaves and the evaluation of its underlying mechanism by using metabolomics analysis.Molecules,25(20).
MLA Chen,Jiali,et al."Anti-inflammatory property of the essential oil from cinnamomum camphora (Linn.) presl leaves and the evaluation of its underlying mechanism by using metabolomics analysis".Molecules 25.20(2020).
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