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Multiple fingerprint profiling for quality evaluation of polysaccharides and related biological activity analysis of Chinese patent drugs: Zishen Yutai Pills as a case study
Li,Hongyi1; Cao,Jiliang1,2,3; Wu,Xu4; Deng,Yun3; Ning,Na5; Geng,Chunxian5; Lei,Ting5; Lin,Ruizhen5; Wu,Dingtao6; Wang,Shengpeng1; Li,Peng1; Wang,Yitao1
2020-10-05
Source PublicationJournal of Ethnopharmacology
ISSN0378-8741
Volume260
Abstract

Ethnopharmacological relevance: Zishen Yutai Pills (ZYP), a famous traditional Chinese patent medicine, has been widely applied to avoid recurrent miscarriage and treat threatened abortion. Polysaccharides of ZYP (ZYPPs) play an essential role in the theraprutic effects of ZYP. However, the complex compositions of ZYP and the complicated structure of ZYPPs have posed great challenges and barriers to the quality evaluation of ZYP. Aim of the study: To identify and characterize the ZYPPs for better quality control of ZYP, a reliable and valid quality control system was established in this study. Materials and methods: A multi-fingerprint profile strategy based on HPSEC-MALL-RID, FT-IR, and HPLC (complete acid digested fingerprint, partial acid digested fingerprint and enzymatically digested fingerprint) was established to identify and discriminate the chemical structure of ZYPPs. Besides, the purpose of revealing the relationships between structure and biological activity of ZYPPs, their chemical characteristics, in vitro antioxidant and anti-glycation activities were investigated and discussed. Results: The similarity evaluation of ZYPPs indicated ZYPPs from different batches showed a high similarity based on the correlation coefficient values of multi-fingerprints. Furthermore, ZYPPs exhibited remarkable antioxidant and antiglycation properties, which might be attributed to their molecular weights and the content of uronic acids. Conclusions: These results indicated that the multiple fingerprint technique was reliable and effective for the improvement of quality control of ZYPPs, suggesting the multiple fingerprint technique could also be potentially applied as a valid and feasible strategy to control the quality of polysaccharide-enriched herbal medicines.

KeywordBiological Activities Multi-fingerprint Polysaccharides Zishen Yutai Pills
DOI10.1016/j.jep.2020.113045
URLView the original
Indexed BySCIE
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000579384200059
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang,Shengpeng
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa, Macao,Macao
2.PU-UM Innovative Institute of Chinese Medical Sciences,Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co.,Ltd,Zhuhai,Hengqin New Area,China
3.College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,China
4.Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou,China
5.Guangzhou Baiyunshan Zhongyi Pharmaceutical Co.,Ltd,Guangzhou,China
6.Institute of Food Processing and Safety,College of Food Science,Sichuan Agricultural University,Ya'an,625014,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li,Hongyi,Cao,Jiliang,Wu,Xu,et al. Multiple fingerprint profiling for quality evaluation of polysaccharides and related biological activity analysis of Chinese patent drugs: Zishen Yutai Pills as a case study[J]. Journal of Ethnopharmacology,2020,260.
APA Li,Hongyi.,Cao,Jiliang.,Wu,Xu.,Deng,Yun.,Ning,Na.,...&Wang,Yitao.(2020).Multiple fingerprint profiling for quality evaluation of polysaccharides and related biological activity analysis of Chinese patent drugs: Zishen Yutai Pills as a case study.Journal of Ethnopharmacology,260.
MLA Li,Hongyi,et al."Multiple fingerprint profiling for quality evaluation of polysaccharides and related biological activity analysis of Chinese patent drugs: Zishen Yutai Pills as a case study".Journal of Ethnopharmacology 260(2020).
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