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Interactions of antithrombotic herbal medicines with Western cardiovascular drugs
Zuo,Hua Li1; Linghu,Ke Gang1; Wang,Ya Li2; Liu,Kun Meng1; Gao,Yan1; Yu,Hua1; Yang,Feng Qing2; Hu,Yuan Jia1
2020-09-01
Source PublicationPharmacological Research
ISSN1043-6618
Volume159
Abstract

Thrombotic events act as a critical factor that interferes with Cardiovascular Diseases (CVDs), and antithrombotic herbal medicine is a long-standing controversial issue. Although a dispute is involved in their clinical application, all parties unanimously agree that herbal products have been widely used in folk medicine, and their interactions with conventional drugs are of high concern. This study aims to investigate how antithrombotic herbal medicines interact with Western cardiovascular drugs on the molecular level by taking an example of the most frequently used herbal pair, Danshen−Chuanxiong (DS−CX), and to discover more scientific evidence on their potential herb−drug interactions. Network pharmacology (NP), as an analytical approach of a complex system, is used to visualize and compare target profiles of DS−CX and Western cardiovascular drugs, which can be applied to predict common herb-drug targets and to construct a solid context for discussing herb−drug interactions. These interactions are further validated by in vitro assays, while in vivo zebrafish model employed for evaluating an overall pharmacological efficacy of herbal pairs in specific combination ratios. The study finds that DS could react directly to the Western cardiovascular drug targets relevant to antithrombotic pathways (i.e., thrombin, coagulation factor Xa and cyclooxygenase-1), whereas CX could not react directly and can synergistically affect antithrombotic effects with DS in specific combination ratios. Moreover, it is indicated that DS−CX may generate wide biological functions by a complicated mechanism of “neuro−immune−metabolism/endocrine” (NIM), which can further cause multiple direct and indirect interactions with Western cardiovascular drugs. From the clinical perspective, herb−drug interactions should be given high attention, especially when multiple herbs are used simultaneously.

KeywordAntithrombotic Herbal Medicine Butylidenephthalide (Pubchem Cid: 642376) Cardiovascular Disease Cryptotanshinone (Pubchem Cid: 160254) Herb−drug Interaction Network Pharmacology Salvianolic ACid a (Pubchem Cid: 5281793) Salvianolic ACid c (Pubchem Cid: 13991590) Senkyunolide c (Pubchem Cid: 642374) Tanshinone i (Pubchem Cid: 114917) Tanshinone Iia (Pubchem Cid: 164676) Western Drugs
DOI10.1016/j.phrs.2020.104963
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000566429500001
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,999078,China
2.School of Chemistry and Chemical Engineering,Chongqing University,Chongqing,401331,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zuo,Hua Li,Linghu,Ke Gang,Wang,Ya Li,et al. Interactions of antithrombotic herbal medicines with Western cardiovascular drugs[J]. Pharmacological Research,2020,159.
APA Zuo,Hua Li.,Linghu,Ke Gang.,Wang,Ya Li.,Liu,Kun Meng.,Gao,Yan.,...&Hu,Yuan Jia.(2020).Interactions of antithrombotic herbal medicines with Western cardiovascular drugs.Pharmacological Research,159.
MLA Zuo,Hua Li,et al."Interactions of antithrombotic herbal medicines with Western cardiovascular drugs".Pharmacological Research 159(2020).
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