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Molecular evidence of herbal formula: a network-based analysis of Si-Wu decoction
Zuo,Hua Li1; Zhang,Qian Ru2; Chen,Cen3; Yang,Feng Qing4; Yu,Hua1; Hu,Yuan Jia1
Source PublicationPhytochemical Analysis

Introduction: Emerging network pharmacology (NP) combines phytochemical information with bioinformatics tools allowing herbal formulae to be illustrated holistically in the context of phytochemical basis and therapeutic mechanisms. Objective: This study attempted to explore the holistic molecular evidence of herbal formula Si-Wu decoction (SWD) by using the method of NP. Material and method: Databases of traditional medicines combined with PubChem, SciFinder, SEA, STRING, and KEGG were employed to gather information for establishing the “compound similarity” (CS) network and the “target–(pathway)–target” (TPT) network. Gephi software was applied to visualise the networks, with further module-based and node-based network topological analysis. Moreover, the approved drugs and shortest path analysis were used to validate the TPT network. Results: The CS network presented the phytochemical profile of SWD, including the major compound groups of iridoid glycosides, glycosides, phthalide lactones, phenylpropanoids, and monoterpenoids. Furthermore, the topological analysis of TPT network depicted the holistic property of SWD in interpretable neuroendocrine immunomodulation (NIM) perspective, and the node degree analysis indicated a closer connection of SWD with endocrine or metabolism system. Moreover, by combing the analysis of the CS network and TPT network, potential active ingredients could be primarily identified. Conclusion: The phytochemical profile and molecular target profile, which might pave the way for an understanding of SWD in modern science and provide a reference for relevant quality research and evaluation, were demonstrated by network analysis. Moreover, the methods could be further applied to discover the phytochemical or biomolecular evidence with distinct advantages in dealing with the tremendous separated information.

KeywordNetwork Module Network Pharmacology Neuroendocrine Immunomodulation Phytochemical Information Si-wu Decoction
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences ; Chemistry
WOS SubjectBiochemical Research Methods ; Plant Sciences ; Chemistry, Analytical
WOS IDWOS:000539018800001
Scopus ID2-s2.0-85086149545
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYu,Hua; Hu,Yuan Jia
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.School of Pharmacy,Zunyi Medical University,China
3.Department of Surgery and Cancer,Faculty of Medicine,Imperial College London,London,United Kingdom
4.School of Chemistry and Chemical Engineering,Chongqing University,Chongqing,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zuo,Hua Li,Zhang,Qian Ru,Chen,Cen,et al. Molecular evidence of herbal formula: a network-based analysis of Si-Wu decoction[J]. Phytochemical Analysis,2021,32(2):198-205.
APA Zuo,Hua Li,Zhang,Qian Ru,Chen,Cen,Yang,Feng Qing,Yu,Hua,&Hu,Yuan Jia.(2021).Molecular evidence of herbal formula: a network-based analysis of Si-Wu decoction.Phytochemical Analysis,32(2),198-205.
MLA Zuo,Hua Li,et al."Molecular evidence of herbal formula: a network-based analysis of Si-Wu decoction".Phytochemical Analysis 32.2(2021):198-205.
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