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Saponins from chinese medicines as anticancer agents
Xu,Xiao Huang1; Li,Ting1; Fong,Chi Man Vivienne1; Chen,Xiuping1; Chen,Xiao Jia1; Wang,Yi Tao1; Huang,Ming Qing2; Lu,Jin Jian1
2016-10-01
Source PublicationMolecules
Volume21Issue:10
AbstractSaponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-Angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.
KeywordCancer Mechanism Steroid Saponins Target Triterpenoid Saponins
DOI10.3390/molecules21101326
URLView the original
Language英语
Scopus ID2-s2.0-84992336060
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Cited Times [WOS]:46   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,350122,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu,Xiao Huang,Li,Ting,Fong,Chi Man Vivienne,et al. Saponins from chinese medicines as anticancer agents[J]. Molecules,2016,21(10).
APA Xu,Xiao Huang,Li,Ting,Fong,Chi Man Vivienne,Chen,Xiuping,Chen,Xiao Jia,Wang,Yi Tao,Huang,Ming Qing,&Lu,Jin Jian.(2016).Saponins from chinese medicines as anticancer agents.Molecules,21(10).
MLA Xu,Xiao Huang,et al."Saponins from chinese medicines as anticancer agents".Molecules 21.10(2016).
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