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Saponins from chinese medicines as anticancer agents
Xu,Xiao Huang1; Li,Ting1; Fong,Chi Man Vivienne1; Chen,Xiuping1; Chen,Xiao Jia1; Wang,Yi Tao1; Huang,Ming Qing2; Lu,Jin Jian1
Source PublicationMolecules
AbstractSaponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-Angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.
KeywordCancer Mechanism Steroid Saponins Target Triterpenoid Saponins
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Scopus ID2-s2.0-84992336060
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,350122,China
First Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Xu,Xiao Huang,Li,Ting,Fong,Chi Man Vivienne,et al. Saponins from chinese medicines as anticancer agents[J]. Molecules,2016,21(10).
APA Xu,Xiao Huang,Li,Ting,Fong,Chi Man Vivienne,Chen,Xiuping,Chen,Xiao Jia,Wang,Yi Tao,Huang,Ming Qing,&Lu,Jin Jian.(2016).Saponins from chinese medicines as anticancer agents.Molecules,21(10).
MLA Xu,Xiao Huang,et al."Saponins from chinese medicines as anticancer agents".Molecules 21.10(2016).
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