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Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge
Chen,Xiuping1,2; Yu,Jie2; Zhong,Bingling2; Lu,Jiahong2; Lu,Jin Jian2; Li,Shaojing3; Lu,Yang4
2019-07-01
Source PublicationPharmacological Research
ISSN1043-6618
Volume145
Abstract

Salvia miltiorrhiza Bunge (Danshen), a famous traditional Chinese herb, has been used clinically for the treatment of various diseases for centuries. Document data showed that tanshinones, a class of lipophilic abietane diterpenes rich in this herb, possess multiple biological effects in vitro and in vivo models. Among which, 15,16-dihydrotanshinone I (DHT)has received much attention in recent years. In this systematical review, we carefully selected, analyzed, and summarized high-quality publications related to pharmacological effects and the underlying mechanisms of DHT. DHT has anti-cancer, cardiovascular protective, anti-inflammation, anti-Alzheimer's disease, and other effects. Furthermore, several molecules such as hypoxia-inducible factor (HIF-1α), human antigen R (HuR), acetylcholinesterase (AchE), etc. have been identified as the potential targets for DHT. The diverse pharmacological activities of DHT provide scientific evidence for the local and traditional uses of Salvia miltiorrhiza Bunge. We concluded that DHT might serve as a lead compound for drug discovery in related diseases while further in-depth investigations are still needed.

Keyword15,16-dihydrotanshinone i Anti-cancer Anti-inflammation Cardiovascular Protection Human Antigen r Hypoxia-inducible Factor
DOI10.1016/j.phrs.2019.104254
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000475721100004
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen,Xiuping
Affiliation1.Medical College,Qingdao University,Qingdao,266071,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,Macao
3.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
4.Beijing Key Laboratory of Polymorphic Drugs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen,Xiuping,Yu,Jie,Zhong,Bingling,et al. Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge[J]. Pharmacological Research,2019,145.
APA Chen,Xiuping,Yu,Jie,Zhong,Bingling,Lu,Jiahong,Lu,Jin Jian,Li,Shaojing,&Lu,Yang.(2019).Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge.Pharmacological Research,145.
MLA Chen,Xiuping,et al."Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge".Pharmacological Research 145(2019).
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