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Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach
Song,Min1; Zhang,Jian2; Chan,Ging1; Hou,Ying1; Chen,Xiu Ping1; Zhang,Xiao Qi2; Ye,Wen Cai2; Zhang,Qing Wen1
2020-11-30
Source PublicationJournal of Natural Products
ISSN0163-3864
Volume83Issue:12Pages:3502-3510
Abstract

Nine new limonoids, meliazedarines A-I (1-9), seven known analogues (10-16), and five known triterpenoids (17-21) were isolated from the fruits of Melia azedarach. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, and electronic circular dichroism (ECD) data. Compound 7 showed significant cytotoxicity against the HCT116 cell line with IC50 values of 0.3 ± 0.1 μM.

DOI10.1021/acs.jnatprod.9b01151
URLView the original
Indexed BySCIE ; IC
Language英語English
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy 4.05
WOS IDWOS:000603402900002
Scopus ID2-s2.0-85097828233
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang,Qing Wen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.Guangdong Provincial Engineering Research Center for Modernization of TCM,College of Pharmacy,Jinan University,Guangzhou,510632,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Song,Min,Zhang,Jian,Chan,Ging,et al. Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach[J]. Journal of Natural Products,2020,83(12):3502-3510.
APA Song,Min,Zhang,Jian,Chan,Ging,Hou,Ying,Chen,Xiu Ping,Zhang,Xiao Qi,Ye,Wen Cai,&Zhang,Qing Wen.(2020).Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach.Journal of Natural Products,83(12),3502-3510.
MLA Song,Min,et al."Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach".Journal of Natural Products 83.12(2020):3502-3510.
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