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Isolation and identification of antiarthritic constituents from glycine tabacina and network pharmacology-based prediction of their protective mechanisms against rheumatoid arthritis
Tu,Yanbei1; Wang,Kai1; Jia,Xuejing2; Tan,Lihua1; Han,Bing1; Zhang,Qingwen1; Li,Yanfang3; He,Chengwei1
2020-06-12
Source PublicationJournal of Agricultural and Food Chemistry
ISSN0021-8561
Volume68Issue:39Pages:10664-10677
Abstract

Glycine tabacina (Labill.) Benth is an edible medicinal herb for rheumatoid arthritis (RA) treatment in folk medicine. Current phytochemical research on this dried herb led to the isolation of eight new coumestans, named glytabastan A-H (1-8), and twenty-three known compounds 9−31. Their structures were elucidated using spectroscopic methods. The antiarthritic activities of all isolates were evaluated, and the results showed that coumestans 1−6 and 8−10 could inhibit arthritic inflammation in vitro, while coumestans 1, 2, 9, and 10 significantly blocked the osteoclastogenesis induced by receptor activator of nuclear factor (NF) κB ligand (RANKL). Moreover, network pharmacological analysis revealed that the anti-RA effect of G. tabacina involved multitargets, multipathways such as PI3K/Akt and MAPK signaling pathways, and various biological processes such as inflammatory response and cytokine-mediated signaling pathways. These results suggested that this species and its novel coumestans could serve as potential antiarthritic agents for functional food or medicinal use.

KeywordCoumestan Glycine Tabacina Inflammation Network Pharmacology Osteoclastogenesis Rheumatoid Arthritis
DOI10.1021/acs.jafc.0c00878
URLView the original
Indexed BySCIE ; IC
Language英語English
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000577116200017
Scopus ID2-s2.0-85086714970
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorHe,Chengwei
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa, Macao,999078,Macao
2.College of Food Science and Technology,Guangdong Ocean University,Zhanjiang,524088,China
3.School of Chemical Engineering,Sichuan University,Chengdu,610065,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tu,Yanbei,Wang,Kai,Jia,Xuejing,et al. Isolation and identification of antiarthritic constituents from glycine tabacina and network pharmacology-based prediction of their protective mechanisms against rheumatoid arthritis[J]. Journal of Agricultural and Food Chemistry,2020,68(39):10664-10677.
APA Tu,Yanbei,Wang,Kai,Jia,Xuejing,Tan,Lihua,Han,Bing,Zhang,Qingwen,Li,Yanfang,&He,Chengwei.(2020).Isolation and identification of antiarthritic constituents from glycine tabacina and network pharmacology-based prediction of their protective mechanisms against rheumatoid arthritis.Journal of Agricultural and Food Chemistry,68(39),10664-10677.
MLA Tu,Yanbei,et al."Isolation and identification of antiarthritic constituents from glycine tabacina and network pharmacology-based prediction of their protective mechanisms against rheumatoid arthritis".Journal of Agricultural and Food Chemistry 68.39(2020):10664-10677.
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