UM
PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer
Cai,Yuee1; Wang,Shengpeng1; Wu,Minghui2; Tsosie,Jonathan K.3; Xie,Xi4; Wan,Jianbo1; He,Chengwei1; Tian,Huayu5; Chen,Xuesi5; Chen,Meiwan1
2016
Source PublicationRSC Advances
Volume6Issue:42Pages:35318-35327
AbstractMitoxantrone (MIT) is a promising candidate for cancer therapy, but the clinical application of MIT is hindered by its multidrug resistance (MDR) effect. Herein, amphiphilic poly(ϵ-caprolactone)-pluronic F68-poly(ϵ-caprolactone) (PFP) and PLGA-PEG-PLGA (PPP) polymers were designed to fabricate mixed micelles for the efficient delivery of MIT with reversed MDR effect. These mixed micelles (MIT-PFP/PPP micelles) exerted favorable particle size of 144.70 ± 10.52 nm and encapsulation efficiency of 56.69 ± 4.67%. Importantly, MIT-PFP/PPP micelles could strongly inhibit cell proliferation in MCF-7/ADR cells with the IC of 3.503 ± 0.163 μM for 24 h, which was about 7.7-fold lower than that of free MIT. The molecular mechanism of reversed MDR effect in MCF-7/ADR cells was ascribed to the downregulation of P-glycoprotein (P-gp) by MIT-PFP/PPP micelles resulting in enhanced anticancer efficacy. These findings suggest that MIT-PFP/PPP micelles have great potential for overcoming MDR effect by inhibiting the protein expression of P-gp in cancer cells.
DOI10.1039/c5ra27648a
URLView the original
Language英语
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Meiwan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,Macao
2.Department of Cell Biology and Anatomy,College of Medicine,University of Florida,Gainesville,32601,United States
3.New Mexico Institute of Mining and Technology,Socorro,87801,United States
4.School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou,510275,China
5.Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cai,Yuee,Wang,Shengpeng,Wu,Minghui,et al. PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer[J]. RSC Advances,2016,6(42):35318-35327.
APA Cai,Yuee,Wang,Shengpeng,Wu,Minghui,Tsosie,Jonathan K.,Xie,Xi,Wan,Jianbo,He,Chengwei,Tian,Huayu,Chen,Xuesi,&Chen,Meiwan.(2016).PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer.RSC Advances,6(42),35318-35327.
MLA Cai,Yuee,et al."PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer".RSC Advances 6.42(2016):35318-35327.
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