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Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs
Wang,Yancai1,2; Miao,Xiaoqing1; Sun,Lin1; Song,Ju1; Bi,Chao1; Yang,Xiao1; Zheng,Ying1
2014
Source PublicationCurrent Pharmaceutical Design
ISSN1381-6128
Volume20Issue:3Pages:454-473
AbstractA surprisingly large proportion of new chemical entities (NCE) is emerging from the drug discovery pipeline, and many active components extracted from herbal medicines are water insoluble, which represents a great challenge for their development. Nanosuspensions, which are submicron colloidal dispersions of pure drug particles that are stabilised by a small percentage of the excipients, could dramatically enhance the saturated solubility, dissolution rate and adhesion of drug particles to cell membranes. Nanosuspensions are the most suitable for drugs that require high dosing or have limited administrative volume. After 20 years of development, several oral products and one injectable product are commercially available. The aim of this review is to fill the gap between rational formulation designs and the in vivo performance of poorly water-soluble drug nanosuspensions. Specifically, this review will correlate characteristics of nanosuspension formulations, including drug property, particle size, crystallinity, stabiliser and surface property, with their transport, pharmacokinetics, bioactivity and toxicity after delivery by different administration routes. The elucidation of the mechanisms of targeted drug delivery, cellular transport and internalisation of nanosuspensions are also reviewed to interpret the in vivo performance of these nanosuspensions. Moreover, the recent application of nanosuspensions for poorly water-soluble herbal medicines is highlighted. © 2014 Bentham Science Publishers.
KeywordAbsorption Drug targeting Efficacy Nanosuspensions Pharmacokinetics Toxicity Transport
DOI10.2174/13816128113199990403
URLView the original
Language英语
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZheng,Ying
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,Macao
2.School of Chemistry and Pharmaceutical Engineering,Shandong Polytechnic University,Jinan 250353,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang,Yancai,Miao,Xiaoqing,Sun,Lin,et al. Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs[J]. Current Pharmaceutical Design,2014,20(3):454-473.
APA Wang,Yancai,Miao,Xiaoqing,Sun,Lin,Song,Ju,Bi,Chao,Yang,Xiao,&Zheng,Ying.(2014).Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs.Current Pharmaceutical Design,20(3),454-473.
MLA Wang,Yancai,et al."Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs".Current Pharmaceutical Design 20.3(2014):454-473.
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