UM
Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines
Chen,Tongkai1; He,Bing2,4; Tao,Jingsong3; He,Yuan3; Deng,Hailiang2; Wang,Xueqing2; Zheng,Ying3
2019-03-15
Source PublicationAdvanced Drug Delivery Reviews
ISSN0169-409X
Volume143Pages:177-205
AbstractExtensive studies on nanomedicines have been conducted for drug delivery and disease diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of nanomedicines, which is significantly associated with their clinical therapeutic effect, is poorly understood at present. This is because of the technical challenges to quantify the disassembly and behaviour of nanomedicines. As a fluorescence- and distance-based approach, the Förster Resonance Energy Transfer (FRET) technique is very successful to study the interaction of nanomedicines with biological systems. In this review, principles on how to select a FRET pair and construct FRET-based nanomedicines have been described first, followed by their application to study structural integrity, biodistribution, disassembly kinetics, and elimination of nanomedicines at intracellular and in vivo levels, especially with drug nanocarriers including polymeric micelles, polymeric nanoparticles, and lipid-based nanoparticles. FRET is a powerful tool to reveal changes and interaction of nanoparticles after delivery, which will be very useful to guide future developments of nanomedicine.
KeywordBiofate Förster Resonance Energy Transfer (FRET) Integrity Lipid-based nanoparticles Micelles Nanomedicines Polymeric Nanoparticles
DOI10.1016/j.addr.2019.04.009
URLView the original
Language英语
Fulltext Access
Citation statistics
Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZheng,Ying
Affiliation1.Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,Guangzhou,510405,China
2.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,China
4.State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing,100191,China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen,Tongkai,He,Bing,Tao,Jingsong,et al. Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines[J]. Advanced Drug Delivery Reviews,2019,143:177-205.
APA Chen,Tongkai,He,Bing,Tao,Jingsong,He,Yuan,Deng,Hailiang,Wang,Xueqing,&Zheng,Ying.(2019).Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines.Advanced Drug Delivery Reviews,143,177-205.
MLA Chen,Tongkai,et al."Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines".Advanced Drug Delivery Reviews 143(2019):177-205.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen,Tongkai]'s Articles
[He,Bing]'s Articles
[Tao,Jingsong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen,Tongkai]'s Articles
[He,Bing]'s Articles
[Tao,Jingsong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen,Tongkai]'s Articles
[He,Bing]'s Articles
[Tao,Jingsong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.