UM
Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies
Wei,Bin1; Yang,Wei1; Yan,Zhi Xiang1; Zhang,Qing Wen1; Yan,Ru1,2
2018-09-01
Source PublicationJournal of Functional Foods
ISSN1756-4646
Volume48Pages:210-219
AbstractGut microbial β-glucuronidases show varied substrate specificity and inhibition propensity, highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet clinical needs. In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG) exhibited strong inhibition on p-nitrophenyl-β-D-glucuronide-hydrolyzing activity in pooled human gut microbiota and eight bacterial isolates, while amoxapine, a previously reported Escherichia coli β-glucuronidase (EcoGUS) inhibitor, only showed poor inhibition on the pooled samples and relatively selective inhibition on individual strains with incomplete inhibition on Staphylococcus.pasteuri 3I10. Both prenylflavonoids exhibited mixed-type inhibition against the recombinant enzymes EcoGUS and S. pasteuri 3I10 β-glucuronidase (SpasGUS). Molecular docking studies predicted phenolic groups of SGC and KWG as key structures interacting with the allosteric site of SpasGUS, while the phenolic hydroxyl (SGC) or benzopyranyl (KWG) group accounts for the hydrogen bond interaction with EcoGUS. The potentials of these broad-spectrum inhibitors in alleviating bacterial β-glucuronidase-mediated drug toxicity/efficacy warrants further investigation.
KeywordHuman gut microbiota Kuwanon G Molecular docking Sanggenon C β-Glucuronidase inhibitor
DOI10.1016/j.jff.2018.07.013
URLView the original
Language英语
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYan,Ru
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.Zhuhai UM Science & Technology Research Institute,Zhuhai,519080,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wei,Bin,Yang,Wei,Yan,Zhi Xiang,et al. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies[J]. Journal of Functional Foods,2018,48:210-219.
APA Wei,Bin,Yang,Wei,Yan,Zhi Xiang,Zhang,Qing Wen,&Yan,Ru.(2018).Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies.Journal of Functional Foods,48,210-219.
MLA Wei,Bin,et al."Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies".Journal of Functional Foods 48(2018):210-219.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wei,Bin]'s Articles
[Yang,Wei]'s Articles
[Yan,Zhi Xiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wei,Bin]'s Articles
[Yang,Wei]'s Articles
[Yan,Zhi Xiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wei,Bin]'s Articles
[Yang,Wei]'s Articles
[Yan,Zhi Xiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.