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Structural characterization and transcript-metabolite correlation network of immunostimulatory effects of sulfated polysaccharides from green alga Ulva pertusa
Han,Yu1; Wu,Yulin1; Li,Guoqiang2; Li,Meiying1; Yan,Ru3; Xu,Zhenlin1; Lei,Hongtao1; Sun,Yuanming1; Duan,Xuewu4; Hu,Lianmei5; Huang,Riming1
2021-04-16
Source PublicationFood Chemistry
ISSN0308-8146
Volume342
AbstractThree water-soluble polysaccharides (UPPs 1–3) were obtained from edible green alga Ulva pertusa. The chemico-physical analyses indicated that UPPs 1–3 possessed molecular weights of 376.7 kDa, 57.21 kDa, and 131.13 kDa, with sulfate contents of 26.01 ± 8.13%, 9.86 ± 3.24%, and 13.32 ± 6.56%, respectively, and composed of arabinose, galactose, glucose, xylose, galacturonic acid, glucuronic acid, and mannuronic acid, with different ratios. The in vitro studies revealed that UPP-1 showed significant effects on the proliferation and phagocytic activity of macrophage, release of nitric oxide, and secretion of cytokines (TNF-α and IL-6). The transcript-metabolite analysis of UPP-1 treated macrophage revealed 4747 differential genes (2416 up-regulated and 2331 down-regulated) and 94 differential metabolites (77 up-regulated and 17 down-regulated) that significantly co-mapped a transcript-metabolite correlation network of biosynthesis of amino acids, glycerophospholipid metabolism, and carbon metabolism. Thus, these findings provide a valuable foundation for the potential application of U. pertusa polysaccharides.
KeywordImmunostimulatory activity Polysaccharide Structural characteristics Ulva pertusa
DOI10.1016/j.foodchem.2020.128537
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorHu,Lianmei
Affiliation1.Guangdong Provincial Key Laboratory of Food Quality and Safety,College of Food Science,South China Agricultural University,Guangzhou,510642,China
2.Department of Food Science and Engineering/South China National Center for Food Safety Research and Development,Foshan University,Foshan,528231,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,Taipa,China
4.Guangdong Provincial Key Laboratory of Applied Botany,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou,510650,China
5.College of Veterinary Medicine,South China Agricultural University,Guangzhou,510642,China
Recommended Citation
GB/T 7714
Han,Yu,Wu,Yulin,Li,Guoqiang,et al. Structural characterization and transcript-metabolite correlation network of immunostimulatory effects of sulfated polysaccharides from green alga Ulva pertusa[J]. Food Chemistry,2021,342.
APA Han,Yu,Wu,Yulin,Li,Guoqiang,Li,Meiying,Yan,Ru,Xu,Zhenlin,Lei,Hongtao,Sun,Yuanming,Duan,Xuewu,Hu,Lianmei,&Huang,Riming.(2021).Structural characterization and transcript-metabolite correlation network of immunostimulatory effects of sulfated polysaccharides from green alga Ulva pertusa.Food Chemistry,342.
MLA Han,Yu,et al."Structural characterization and transcript-metabolite correlation network of immunostimulatory effects of sulfated polysaccharides from green alga Ulva pertusa".Food Chemistry 342(2021).
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