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Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments
Peng,Yu; Shi,Zhe; Kumaran Satyanarayanan,Senthil; He,Chengwei; Li,Peng; Wan,Jian Bo; Su,Huanxing
2020-11-01
Source PublicationBrain, Behavior, and Immunity
ISSN0889-1591
Volume90Pages:393-402
Abstract

Our previous study revealed that fish oil (FO) pre-treatment could improve the lipopolysaccharides (LPS)-induced depressive-like behavior in mice but did not alter the expression of stress hormones associated with the hypothalamic–pituitary–adrenal (HPA) axis. The exact mechanisms underlying the protective effects of FO remain elusive. Here we applied the metabolomic technique to investigate the potential involvement of FO metabolites in ameliorating depressive-like behaviors in LPS-injected mice. It revealed that LPS-injection stimulated systemic inflammation, exhausted the nicotinamide adenine dinucleotide (NAD) level in the brain, decreased energy metabolism and impaired neuronal function, which collectively contributed to depressive-like behaviors in mice. FO treatment enhanced the production of neuroprotective metabolites including taurine, hypotaurine and tyramine, decreased the generation of neurotoxic agents such as ADPR, glutamate accumulation and oxidized glutathione, and prevented the NAD exhaustion in the brain, which might underlie the beneficial effects of FO against LPS-induced inflammation and depressive-like behaviors.

KeywordDepression Metabolomics Molecular Pathways Neuroinflammation Systemic Inflammation
DOI10.1016/j.bbi.2020.09.005
URLView the original
Indexed BySCIE
WOS Research AreaImmunology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectImmunology ; Neurosciences ; Psychiatry
WOS IDWOS:000577976900038
Scopus ID2-s2.0-85090827535
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu,Huanxing
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Peng,Yu,Shi,Zhe,Kumaran Satyanarayanan,Senthil,et al. Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments[J]. Brain, Behavior, and Immunity,2020,90:393-402.
APA Peng,Yu,Shi,Zhe,Kumaran Satyanarayanan,Senthil,He,Chengwei,Li,Peng,Wan,Jian Bo,&Su,Huanxing.(2020).Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments.Brain, Behavior, and Immunity,90,393-402.
MLA Peng,Yu,et al."Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments".Brain, Behavior, and Immunity 90(2020):393-402.
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