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Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota
Li,Lifeng1,2; Yao,Hong3; Li,Xiaojun1; Zhang,Quanwei1; Wu,Xiyang3; Wong,Tinlong1; Zheng,Hongming1; Fung,Hauyee1; Yang,Bingxun4; Ma,Diklung5; Leung,Chunghang6; Zhang,Ge1; Bian,Zhaoxiang1; Lu,Aiping1; Han,Quanbin1,2
2019-05-29
Source PublicationJournal of Agricultural and Food Chemistry
ISSN0021-8561
Volume67Issue:21Pages:5968-5977
AbstractPolysaccharides from functional foods have been proved to have diverse bioactivities, but little is known about what exactly happens to these polysaccharides after oral administration and even less about the underlying mechanism of action. Taking the marker polysaccharide (DOP) of Dendrobium officinale as an example, this study aims to demonstrate the dynamic distribution and degradation of orally dosed DOP in mice and in vitro using near-infrared fluorescence imaging and a kind of chromatographic analysis. The results indicate that (1) neither DOP nor fluorescence-labeled DOP (FDOP) was absorbed, (2) both DOP and FDOP were undigested and were quickly degraded to short-chain fatty acids in the large intestine, (3) DOP modulated gut microbiota, which could be associated with DOP's suppression of 4T1 tumor growth in mice. All of these findings suggest that some (maybe not all) bioactive polysaccharides share a common destiny: indigestible and nonabsorbing, ends in modulating bioactivities-associated gut microbiota.
Keywordabsorption antitumor Dendrobium officinale digestion gut microbiota polysaccharide
DOI10.1021/acs.jafc.9b01489
URLView the original
Language英语
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorHan,Quanbin
Affiliation1.School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,Hong Kong
2.Shenzhen Research Institute,Hong Kong Baptist University,Shenzhen, Guangdong,China
3.Department of Food Science and Engineering,Jinan University,Guangzhou, Guangdong Province,601 Huangpu Road,510632,China
4.Technology Development Center,Zhejiang Tianhuang Medical Plant Pharmaceutical Company,Limited,Hangzhou, Zhejiang Province,88 Wenyi West Road,310012,China
5.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,Hong Kong
6.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
Recommended Citation
GB/T 7714
Li,Lifeng,Yao,Hong,Li,Xiaojun,et al. Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota[J]. Journal of Agricultural and Food Chemistry,2019,67(21):5968-5977.
APA Li,Lifeng,Yao,Hong,Li,Xiaojun,Zhang,Quanwei,Wu,Xiyang,Wong,Tinlong,Zheng,Hongming,Fung,Hauyee,Yang,Bingxun,Ma,Diklung,Leung,Chunghang,Zhang,Ge,Bian,Zhaoxiang,Lu,Aiping,&Han,Quanbin.(2019).Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota.Journal of Agricultural and Food Chemistry,67(21),5968-5977.
MLA Li,Lifeng,et al."Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota".Journal of Agricultural and Food Chemistry 67.21(2019):5968-5977.
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